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- W2000908502 abstract "No study has yet demonstrated an inward current in response to pheromonal substances in vomeronasal sensory neurons. Using female rat vomeronasal sensory neurons, we here successfully recorded inward currents in response to urine from various sources. Of the neurons that responded to urine, 77% responded to only one type of urine. Male Wistar urine induced responses preferentially in the apical layer of the sensory epithelium, whilst male Donryu and female Wistar urine induced responses mainly in the basal layer of the epithelium. The amplitude of inward currents induced by application of male Wistar urine was voltage-dependent with average amplitude of -47.1+/-6.2 pA at -74 mV. The average reversal potential for male Wistar urine was -9.3 +/-6.1 mV, which was not apparently different from the reversal potentials for urine from different species. It is likely that the urine-induced inward currents in response to different types of urine are mediated via a similar channel. The simultaneous removal of Na+ and Ca2+ from extracellular solution eliminated the response. The magnitude of the urine-induced inward current in Cl--free external solution was similar to that in normal solution, suggesting that the urine-induced current is cation selective. Removal of external Ca2+ enhanced the amplitude of the urine-induced current and prolonged the response. Application of the constant-field equation indicated a very high permeability coefficient for Ca2+. This study first demonstrated that substances contained in urine elicited inward currents, which induce an excitatory response in vomeronasal sensory neurons, through cation-selective channels." @default.
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- W2000908502 date "2000-10-01" @default.
- W2000908502 modified "2023-10-05" @default.
- W2000908502 title "Inward current responses to urinary substances in rat vomeronasal sensory neurons" @default.
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- W2000908502 doi "https://doi.org/10.1046/j.1460-9568.2000.00233.x" @default.
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