Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000908765> ?p ?o ?g. }
- W2000908765 endingPage "130" @default.
- W2000908765 startingPage "121" @default.
- W2000908765 abstract "E2, along with Erns and E1, is an envelope glycoprotein of Classical Swine Fever Virus (CSFV). E2 is involved in several virus functions: cell attachment, host range susceptibility and virulence in natural hosts. Here we evaluate the role of a specific E2 region, 818CPIGWTGVIEC828, containing a putative fusion peptide (FP) sequence. Reverse genetics utilizing a full-length infectious clone of the highly virulent CSFV strain Brescia (BICv) was used to evaluate how individual amino acid substitutions within this region of E2 may affect replication of BICv. A synthetic peptide representing the complete E2 FP amino acid sequence adopted a β-type extended conformation in membrane mimetics, penetrated into model membranes, and perturbed lipid bilayer integrity in vitro. Similar peptides harboring amino acid substitutions adopted comparable conformations but exhibited different membrane activities. Therefore, a preliminary characterization of the putative FP 818CPIGWTGVIEC828 indicates a membrane fusion activity and a critical role in virus replication." @default.
- W2000908765 created "2016-06-24" @default.
- W2000908765 creator A5041826188 @default.
- W2000908765 creator A5053127390 @default.
- W2000908765 creator A5056933213 @default.
- W2000908765 creator A5057325307 @default.
- W2000908765 creator A5060425242 @default.
- W2000908765 creator A5074959879 @default.
- W2000908765 creator A5075975834 @default.
- W2000908765 creator A5078846389 @default.
- W2000908765 creator A5083565961 @default.
- W2000908765 date "2014-05-01" @default.
- W2000908765 modified "2023-10-06" @default.
- W2000908765 title "Effect of specific amino acid substitutions in the putative fusion peptide of structural glycoprotein E2 on Classical Swine Fever Virus replication" @default.
- W2000908765 cites W1544234519 @default.
- W2000908765 cites W1593781333 @default.
- W2000908765 cites W1599389506 @default.
- W2000908765 cites W1978958747 @default.
- W2000908765 cites W1985207757 @default.
- W2000908765 cites W1993347536 @default.
- W2000908765 cites W2003375518 @default.
- W2000908765 cites W2003566533 @default.
- W2000908765 cites W2010133215 @default.
- W2000908765 cites W2010133928 @default.
- W2000908765 cites W2012247345 @default.
- W2000908765 cites W2014021406 @default.
- W2000908765 cites W2014922422 @default.
- W2000908765 cites W2034878866 @default.
- W2000908765 cites W2039277389 @default.
- W2000908765 cites W2039774355 @default.
- W2000908765 cites W2045155470 @default.
- W2000908765 cites W2048235504 @default.
- W2000908765 cites W2051553690 @default.
- W2000908765 cites W2054667493 @default.
- W2000908765 cites W2062448305 @default.
- W2000908765 cites W2071507299 @default.
- W2000908765 cites W2072576519 @default.
- W2000908765 cites W2072897393 @default.
- W2000908765 cites W2080557596 @default.
- W2000908765 cites W2083406763 @default.
- W2000908765 cites W2084643139 @default.
- W2000908765 cites W2089521177 @default.
- W2000908765 cites W2105988008 @default.
- W2000908765 cites W2106218159 @default.
- W2000908765 cites W2136238132 @default.
- W2000908765 cites W2136900614 @default.
- W2000908765 cites W2138270253 @default.
- W2000908765 cites W2159081251 @default.
- W2000908765 cites W2159776316 @default.
- W2000908765 cites W2160972243 @default.
- W2000908765 doi "https://doi.org/10.1016/j.virol.2014.03.005" @default.
- W2000908765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24889231" @default.
- W2000908765 hasPublicationYear "2014" @default.
- W2000908765 type Work @default.
- W2000908765 sameAs 2000908765 @default.
- W2000908765 citedByCount "21" @default.
- W2000908765 countsByYear W20009087652015 @default.
- W2000908765 countsByYear W20009087652016 @default.
- W2000908765 countsByYear W20009087652017 @default.
- W2000908765 countsByYear W20009087652018 @default.
- W2000908765 countsByYear W20009087652020 @default.
- W2000908765 countsByYear W20009087652021 @default.
- W2000908765 countsByYear W20009087652023 @default.
- W2000908765 crossrefType "journal-article" @default.
- W2000908765 hasAuthorship W2000908765A5041826188 @default.
- W2000908765 hasAuthorship W2000908765A5053127390 @default.
- W2000908765 hasAuthorship W2000908765A5056933213 @default.
- W2000908765 hasAuthorship W2000908765A5057325307 @default.
- W2000908765 hasAuthorship W2000908765A5060425242 @default.
- W2000908765 hasAuthorship W2000908765A5074959879 @default.
- W2000908765 hasAuthorship W2000908765A5075975834 @default.
- W2000908765 hasAuthorship W2000908765A5078846389 @default.
- W2000908765 hasAuthorship W2000908765A5083565961 @default.
- W2000908765 hasBestOaLocation W20009087651 @default.
- W2000908765 hasConcept C103038307 @default.
- W2000908765 hasConcept C104317684 @default.
- W2000908765 hasConcept C108625454 @default.
- W2000908765 hasConcept C140704245 @default.
- W2000908765 hasConcept C159047783 @default.
- W2000908765 hasConcept C167625842 @default.
- W2000908765 hasConcept C202751555 @default.
- W2000908765 hasConcept C2522874641 @default.
- W2000908765 hasConcept C2779281246 @default.
- W2000908765 hasConcept C515207424 @default.
- W2000908765 hasConcept C55493867 @default.
- W2000908765 hasConcept C60987743 @default.
- W2000908765 hasConcept C86803240 @default.
- W2000908765 hasConceptScore W2000908765C103038307 @default.
- W2000908765 hasConceptScore W2000908765C104317684 @default.
- W2000908765 hasConceptScore W2000908765C108625454 @default.
- W2000908765 hasConceptScore W2000908765C140704245 @default.
- W2000908765 hasConceptScore W2000908765C159047783 @default.
- W2000908765 hasConceptScore W2000908765C167625842 @default.
- W2000908765 hasConceptScore W2000908765C202751555 @default.
- W2000908765 hasConceptScore W2000908765C2522874641 @default.
- W2000908765 hasConceptScore W2000908765C2779281246 @default.
- W2000908765 hasConceptScore W2000908765C515207424 @default.
- W2000908765 hasConceptScore W2000908765C55493867 @default.