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- W2000910321 abstract "Granulocyte-colony stimulating factor (G-CSF) is used clinically for treating chemotherapy-induced neutropenia (low neutrophil levels). Here we present a delay differential equation model for the regulation of neutrophil production that accounts for the effects of G-CSF. Using a combination of analysis and numerical simulations, we use this model to study the effects of delaying G-CSF treatment following chemotherapy for two recombinant forms of G-CSF (filgrastim and pegfilgrastim). We also examine the consequences of varying the duration of filgrastim treatment. We found that varying the starting day or the duration of G-CSF treatment can lead to different qualitative responses in the neutrophil count. These changes can be explained by the coexistence of two stable solutions in the mathematical model." @default.
- W2000910321 created "2016-06-24" @default.
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- W2000910321 date "2009-03-01" @default.
- W2000910321 modified "2023-10-07" @default.
- W2000910321 title "Mathematical model for G-CSF administration after chemotherapy" @default.
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- W2000910321 doi "https://doi.org/10.1016/j.jtbi.2008.09.043" @default.
- W2000910321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19007795" @default.
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