FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000912214> ?p ?o ?g. }

• W2000912214 endingPage "1199" @default.
• W2000912214 startingPage "1187" @default.
• W2000912214 abstract "Though lactoferrin (LF) is a glycoprotein that is involved in immunomodulation, its action mechanism has not been fully elucidated. Previous studies have suggested that lipopolysaccharide (LPS) activity is inhibited by direct binding between LPS and LF. However, here we show that when LPS and purified LF was mixed, and formed a complex (termed as LF–LPS), it was found to induce production of inflammatory mediators in macrophages to some extent, rather than inhibit LPS activity. Moreover, when macrophages were pretreated with LF–LPS, cells were rendered a tolerant state to LPS challenge. These macrophage-activating effects were mediated by Toll-like receptor 4 (TLR4)-NF-κB pathway. Comparative studies with C3H/HeN and C3H/HeJ mice demonstrated the strong dependency of the LF–LPS signal on TLR4. These findings suggest that the immunomodulatory properties of LF could be due, in part, to LPS binding." @default.
• W2000912214 created "2016-06-24" @default.
• W2000912214 creator A5025448261 @default.
• W2000912214 creator A5027456942 @default.
• W2000912214 creator A5035920145 @default.
• W2000912214 creator A5037752945 @default.
• W2000912214 creator A5039341214 @default.
• W2000912214 creator A5047914569 @default.
• W2000912214 creator A5055429910 @default.
• W2000912214 creator A5065628822 @default.
• W2000912214 date "2004-09-01" @default.
• W2000912214 modified "2023-10-09" @default.
• W2000912214 title "Lactoferrin works as a new LPS-binding protein in inflammatory activation of macrophages" @default.
• W2000912214 cites W1483162601 @default.
• W2000912214 cites W1655860314 @default.
• W2000912214 cites W1769256032 @default.
• W2000912214 cites W1948838079 @default.
• W2000912214 cites W1986472850 @default.
• W2000912214 cites W1990802251 @default.
• W2000912214 cites W1991236622 @default.
• W2000912214 cites W1992456193 @default.
• W2000912214 cites W2004072697 @default.
• W2000912214 cites W2005047699 @default.
• W2000912214 cites W2016383542 @default.
• W2000912214 cites W2029157767 @default.
• W2000912214 cites W2031202929 @default.
• W2000912214 cites W2039713566 @default.
• W2000912214 cites W2053252435 @default.
• W2000912214 cites W2054310214 @default.
• W2000912214 cites W2075055228 @default.
• W2000912214 cites W2086379285 @default.
• W2000912214 cites W2092591554 @default.
• W2000912214 cites W2099796906 @default.
• W2000912214 cites W2106772897 @default.
• W2000912214 cites W2113195286 @default.
• W2000912214 cites W2113423265 @default.
• W2000912214 cites W2115929723 @default.
• W2000912214 cites W2116541052 @default.
• W2000912214 cites W2120227455 @default.
• W2000912214 cites W2122708604 @default.
• W2000912214 cites W2141806110 @default.
• W2000912214 cites W2147094062 @default.
• W2000912214 cites W2158799013 @default.
• W2000912214 cites W2159542631 @default.
• W2000912214 cites W2164685578 @default.
• W2000912214 cites W2368227213 @default.
• W2000912214 cites W4248387811 @default.
• W2000912214 cites W4254958847 @default.
• W2000912214 cites W4366064347 @default.
• W2000912214 cites W49088916 @default.
• W2000912214 doi "https://doi.org/10.1016/j.intimp.2004.05.009" @default.
• W2000912214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15251114" @default.
• W2000912214 hasPublicationYear "2004" @default.
• W2000912214 type Work @default.
• W2000912214 sameAs 2000912214 @default.
• W2000912214 citedByCount "70" @default.
• W2000912214 countsByYear W20009122142012 @default.
• W2000912214 countsByYear W20009122142013 @default.
• W2000912214 countsByYear W20009122142014 @default.
• W2000912214 countsByYear W20009122142015 @default.
• W2000912214 countsByYear W20009122142016 @default.
• W2000912214 countsByYear W20009122142017 @default.
• W2000912214 countsByYear W20009122142018 @default.
• W2000912214 countsByYear W20009122142019 @default.
• W2000912214 countsByYear W20009122142020 @default.
• W2000912214 countsByYear W20009122142021 @default.
• W2000912214 countsByYear W20009122142022 @default.
• W2000912214 countsByYear W20009122142023 @default.
• W2000912214 crossrefType "journal-article" @default.
• W2000912214 hasAuthorship W2000912214A5025448261 @default.
• W2000912214 hasAuthorship W2000912214A5027456942 @default.
• W2000912214 hasAuthorship W2000912214A5035920145 @default.
• W2000912214 hasAuthorship W2000912214A5037752945 @default.
• W2000912214 hasAuthorship W2000912214A5039341214 @default.
• W2000912214 hasAuthorship W2000912214A5047914569 @default.
• W2000912214 hasAuthorship W2000912214A5055429910 @default.
• W2000912214 hasAuthorship W2000912214A5065628822 @default.
• W2000912214 hasConcept C136449434 @default.
• W2000912214 hasConcept C170493617 @default.
• W2000912214 hasConcept C185592680 @default.
• W2000912214 hasConcept C202751555 @default.
• W2000912214 hasConcept C203014093 @default.
• W2000912214 hasConcept C2776070231 @default.
• W2000912214 hasConcept C2776120743 @default.
• W2000912214 hasConcept C2776709828 @default.
• W2000912214 hasConcept C2776914184 @default.
• W2000912214 hasConcept C2778754761 @default.
• W2000912214 hasConcept C2779170986 @default.
• W2000912214 hasConcept C2779244956 @default.
• W2000912214 hasConcept C55493867 @default.
• W2000912214 hasConcept C62478195 @default.
• W2000912214 hasConcept C86803240 @default.
• W2000912214 hasConcept C95444343 @default.
• W2000912214 hasConceptScore W2000912214C136449434 @default.
• W2000912214 hasConceptScore W2000912214C170493617 @default.
• W2000912214 hasConceptScore W2000912214C185592680 @default.
• W2000912214 hasConceptScore W2000912214C202751555 @default.
• W2000912214 hasConceptScore W2000912214C203014093 @default.

• next