FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000917313> ?p ?o ?g. }

• W2000917313 endingPage "190" @default.
• W2000917313 startingPage "172" @default.
• W2000917313 abstract "Normal pregnancy is associated with significant hemodynamic changes in the cardiovascular system in order to meet the metabolic demands of mother and fetus. These changes include increased cardiac output, decreased vascular resistance, and vascular remodeling in the uterine and systemic circulation. Preeclampsia (PE) is a major complication of pregnancy characterized by proteinuria and hypertension. Several risk factors have been implicated in the pathogenesis of PE including genetic and dietary factors. Ca2+ is an essential dietary element and an important regulator of many cellular processes including vascular function. The importance of adequate dietary Ca2+ intake during pregnancy is supported by many studies. Pregnancy-associated changes in Ca2+ metabolism and plasma Ca2+ have been observed. During pregnancy, changes in intracellular free Ca2+ concentration ([Ca2+]i) have been described in red blood cells, platelets and immune cells. Also, during pregnancy, an increase in [Ca2+]i in endothelial cells (EC) stimulates the production of vasodilator substances such as nitric oxide and prostacyclin. Normal pregnancy is also associated with decreased vascular smooth muscle (VSM) [Ca2+]i and possibly the Ca2+-sensitization pathways of VSM contraction including protein kinase C, Rho-kinase, and mitogen-activated protein kinase. Ca2+-dependent matrix metalloproteinases could also promote extracellular matrix degradation and vascular remodeling during pregnancy. Disruption in the balance between dietary, plasma and vascular cell Ca2+ may be responsible for some of the manifestations of PE including procoagulation, decreased vasodilation, and increased vasoconstriction and vascular resistance. The potential benefits of Ca2+ supplements during pregnancy, and the use of modulators of vascular Ca2+ to reduce the manifestations of PE in susceptible women remain an important area for experimental and clinical research. Keywords: Calcium, pregnancy, hypertension, preeclampsia, endothelium, smooth muscle" @default.
• W2000917313 created "2016-06-24" @default.
• W2000917313 creator A5016791256 @default.
• W2000917313 creator A5056451764 @default.
• W2000917313 creator A5063840461 @default.
• W2000917313 date "2009-09-01" @default.
• W2000917313 modified "2023-10-16" @default.
• W2000917313 title "Vascular and Cellular Calcium in Normal and Hypertensive Pregnancy" @default.
• W2000917313 cites W104252332 @default.
• W2000917313 cites W1597787921 @default.
• W2000917313 cites W160677419 @default.
• W2000917313 cites W172038636 @default.
• W2000917313 cites W180776524 @default.
• W2000917313 cites W1813395305 @default.
• W2000917313 cites W1858680866 @default.
• W2000917313 cites W1889267877 @default.
• W2000917313 cites W1891115592 @default.
• W2000917313 cites W1900611191 @default.
• W2000917313 cites W1963499923 @default.
• W2000917313 cites W1964105744 @default.
• W2000917313 cites W1964615624 @default.
• W2000917313 cites W1967405806 @default.
• W2000917313 cites W1968031755 @default.
• W2000917313 cites W1968036856 @default.
• W2000917313 cites W1968785526 @default.
• W2000917313 cites W1968924786 @default.
• W2000917313 cites W1969892023 @default.
• W2000917313 cites W1970194124 @default.
• W2000917313 cites W1971681123 @default.
• W2000917313 cites W1972077069 @default.
• W2000917313 cites W1972844004 @default.
• W2000917313 cites W1972872808 @default.
• W2000917313 cites W1972953521 @default.
• W2000917313 cites W1973463838 @default.
• W2000917313 cites W1973986621 @default.
• W2000917313 cites W1974373939 @default.
• W2000917313 cites W1975609281 @default.
• W2000917313 cites W1975805306 @default.
• W2000917313 cites W1978289920 @default.
• W2000917313 cites W1979045591 @default.
• W2000917313 cites W1979216766 @default.
• W2000917313 cites W1980247868 @default.
• W2000917313 cites W1980421688 @default.
• W2000917313 cites W1980576961 @default.
• W2000917313 cites W1980764894 @default.
• W2000917313 cites W1982696778 @default.
• W2000917313 cites W1982696903 @default.
• W2000917313 cites W1983209772 @default.
• W2000917313 cites W1983584210 @default.
• W2000917313 cites W1985034480 @default.
• W2000917313 cites W1986469266 @default.
• W2000917313 cites W1986568690 @default.
• W2000917313 cites W1987760275 @default.
• W2000917313 cites W1988431415 @default.
• W2000917313 cites W1988436986 @default.
• W2000917313 cites W1988880326 @default.
• W2000917313 cites W1988924220 @default.
• W2000917313 cites W1990085197 @default.
• W2000917313 cites W1992764416 @default.
• W2000917313 cites W1992912798 @default.
• W2000917313 cites W1993051861 @default.
• W2000917313 cites W1993578290 @default.
• W2000917313 cites W1993930371 @default.
• W2000917313 cites W1996413050 @default.
• W2000917313 cites W1996698109 @default.
• W2000917313 cites W1997131153 @default.
• W2000917313 cites W2000764773 @default.
• W2000917313 cites W2001163438 @default.
• W2000917313 cites W2001600264 @default.
• W2000917313 cites W2007508651 @default.
• W2000917313 cites W2010253027 @default.
• W2000917313 cites W2010382458 @default.
• W2000917313 cites W2015893689 @default.
• W2000917313 cites W2016129882 @default.
• W2000917313 cites W2017543118 @default.
• W2000917313 cites W2017673011 @default.
• W2000917313 cites W2017916839 @default.
• W2000917313 cites W2018101072 @default.
• W2000917313 cites W2019047076 @default.
• W2000917313 cites W2020023248 @default.
• W2000917313 cites W2022322461 @default.
• W2000917313 cites W2023762001 @default.
• W2000917313 cites W2024266861 @default.
• W2000917313 cites W2024716223 @default.
• W2000917313 cites W2025472908 @default.
• W2000917313 cites W2027487830 @default.
• W2000917313 cites W2028336511 @default.
• W2000917313 cites W2028386521 @default.
• W2000917313 cites W2029058414 @default.
• W2000917313 cites W2031495220 @default.
• W2000917313 cites W2032562223 @default.
• W2000917313 cites W2041517672 @default.
• W2000917313 cites W2041665435 @default.
• W2000917313 cites W2043587114 @default.
• W2000917313 cites W2045826494 @default.
• W2000917313 cites W2047006167 @default.
• W2000917313 cites W2049820149 @default.
• W2000917313 cites W2050403225 @default.

• next