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• W2000920190 abstract "beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increased head-dip latency compared to non-stressed controls in the hole-board test, reflecting increased stress-induced behaviors. However, prior administration of beta-LT improved the behaviors caused by stress. The anti-stress effect of beta-LT was blocked by levocabastine, a neurotensin receptor subtype 2 (NTR2) antagonist. In the fear-conditioning test, the duration of freezing responses by cued fear conditioning was significantly reduced in mice administered beta-LT compared with control mice. These results suggest that beta-LT has an anti-stress effect and promotes the extinction of fear memory, which may be mediated by NTR2." @default.
• W2000920190 created "2016-06-24" @default.
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• W2000920190 date "2006-12-01" @default.
• W2000920190 modified "2023-10-08" @default.
• W2000920190 title "Effect of β-lactotensin on acute stress and fear memory" @default.
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• W2000920190 doi "https://doi.org/10.1016/j.peptides.2006.08.009" @default.
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