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• W2000920909 abstract "Abstract Metallic elements and their organic compounds have dynamic regulatory functions in cells. In this study, we implemented a new approach to investigate the mechanism of differentiation of embryonic stem cells, by measuring and analyzing the change in distribution and chemical states of intracellular trace elements. We anticipate that trace metal elements and metalloproteins play important roles in the direction of differentiation, both as active centers, and as factors in the death of neural cells in neurodegenerative disorders. The aim of this study is to analyze the distribution and chemical states of trace elements during the process of differentiation of mouse embryonic stem cells, and to understand how these factors relate to the differentiation process. Using the experimental results, some previously unexplained points are considered, namely (1) how the intracellular elements change during the process of neuronal differentiation, and (2) what the optimal conditions of such elements are for neuronal differentiation. The information obtained during this study is relevant to nervous system development and evolution." @default.
• W2000920909 created "2016-06-24" @default.
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• W2000920909 date "2004-07-01" @default.
• W2000920909 modified "2023-09-27" @default.
• W2000920909 title "An investigation of changes in element distribution and chemical states during differentiation of embryonic stem cells" @default.
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• W2000920909 doi "https://doi.org/10.1016/j.elspec.2004.02.151" @default.
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