Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000921192> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2000921192 endingPage "870" @default.
- W2000921192 startingPage "866" @default.
- W2000921192 abstract "BACKGROUND One patient with metastatic squamous cell carcinoma of the larynx and one with advanced non-Hodgkin lymphoma, both with poor nutritional status, developed ecchymoses and demonstrated prolonged bleeding time and abnormal aggregation of platelets. METHODS On the basis of previous studies, the author measured the level of zinc in the serum and urine of these patients and the effect of zinc supplementation on the clinical symptoms and laboratory findings. Also studied were serum and urine zinc levels in 15 newly diagnosed, untreated cancer patients with no evidence of bleeding. RESULTS The two patients were found to have very low serum and urine zinc levels, which were 6 and 9 μg/dL and 28 and 22 μg/24 hours, respectively, compared with normal average values of 70–150 μg/dL and 150–1200 μg/24 hours. The mean values of zinc in the serum and urine of the 15 patients newly diagnosed with cancer were 109.18 μg/dL and 433.8 μg/24 hours, respectively. Oral administration of zinc without any additional therapy was rapidly followed by control of bleeding, normalization of bleeding time, and platelet aggregation. Discontinuation of zinc caused the return of bleeding and abnormal laboratory findings, which again were corrected with zinc supplementation. CONCLUSIONS Severe depletion of zinc in two patients with advanced cancer and malnutrition was accompanied by cutaneous bleeding and laboratory findings of platelet dysfunction, both of which were corrected by oral supplementation of zinc and reoccurred on discontinuing therapy. Zinc deficiency should be suspected in patients with advanced cancer demonstrating bleeding when a prolonged bleeding time is the only hemostatic abnormality. Cancer 1999;86:866–70. © 1999 American Cancer Society." @default.
- W2000921192 created "2016-06-24" @default.
- W2000921192 creator A5077755105 @default.
- W2000921192 date "1999-09-01" @default.
- W2000921192 modified "2023-10-16" @default.
- W2000921192 title "Cutaneous bleeding related to zinc deficiency in two cases of advanced cancer" @default.
- W2000921192 cites W1757285873 @default.
- W2000921192 cites W1915197178 @default.
- W2000921192 cites W1983250984 @default.
- W2000921192 cites W1984735470 @default.
- W2000921192 cites W2002388317 @default.
- W2000921192 cites W2034468752 @default.
- W2000921192 cites W2056520086 @default.
- W2000921192 cites W2064942376 @default.
- W2000921192 cites W2076445404 @default.
- W2000921192 cites W2077420720 @default.
- W2000921192 cites W2077726139 @default.
- W2000921192 cites W2141715568 @default.
- W2000921192 cites W2151138214 @default.
- W2000921192 cites W2417241526 @default.
- W2000921192 cites W321003982 @default.
- W2000921192 doi "https://doi.org/10.1002/(sici)1097-0142(19990901)86:5<866::aid-cncr24>3.0.co;2-a" @default.
- W2000921192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10463987" @default.
- W2000921192 hasPublicationYear "1999" @default.
- W2000921192 type Work @default.
- W2000921192 sameAs 2000921192 @default.
- W2000921192 citedByCount "23" @default.
- W2000921192 countsByYear W20009211922013 @default.
- W2000921192 countsByYear W20009211922015 @default.
- W2000921192 countsByYear W20009211922016 @default.
- W2000921192 countsByYear W20009211922018 @default.
- W2000921192 countsByYear W20009211922019 @default.
- W2000921192 countsByYear W20009211922020 @default.
- W2000921192 countsByYear W20009211922021 @default.
- W2000921192 countsByYear W20009211922023 @default.
- W2000921192 crossrefType "journal-article" @default.
- W2000921192 hasAuthorship W2000921192A5077755105 @default.
- W2000921192 hasBestOaLocation W20009211921 @default.
- W2000921192 hasConcept C121608353 @default.
- W2000921192 hasConcept C126322002 @default.
- W2000921192 hasConcept C141071460 @default.
- W2000921192 hasConcept C142724271 @default.
- W2000921192 hasConcept C14522933 @default.
- W2000921192 hasConcept C191897082 @default.
- W2000921192 hasConcept C192562407 @default.
- W2000921192 hasConcept C2776928490 @default.
- W2000921192 hasConcept C2778715236 @default.
- W2000921192 hasConcept C2780026642 @default.
- W2000921192 hasConcept C535196362 @default.
- W2000921192 hasConcept C71924100 @default.
- W2000921192 hasConcept C89560881 @default.
- W2000921192 hasConcept C90924648 @default.
- W2000921192 hasConceptScore W2000921192C121608353 @default.
- W2000921192 hasConceptScore W2000921192C126322002 @default.
- W2000921192 hasConceptScore W2000921192C141071460 @default.
- W2000921192 hasConceptScore W2000921192C142724271 @default.
- W2000921192 hasConceptScore W2000921192C14522933 @default.
- W2000921192 hasConceptScore W2000921192C191897082 @default.
- W2000921192 hasConceptScore W2000921192C192562407 @default.
- W2000921192 hasConceptScore W2000921192C2776928490 @default.
- W2000921192 hasConceptScore W2000921192C2778715236 @default.
- W2000921192 hasConceptScore W2000921192C2780026642 @default.
- W2000921192 hasConceptScore W2000921192C535196362 @default.
- W2000921192 hasConceptScore W2000921192C71924100 @default.
- W2000921192 hasConceptScore W2000921192C89560881 @default.
- W2000921192 hasConceptScore W2000921192C90924648 @default.
- W2000921192 hasIssue "5" @default.
- W2000921192 hasLocation W20009211921 @default.
- W2000921192 hasLocation W20009211922 @default.
- W2000921192 hasOpenAccess W2000921192 @default.
- W2000921192 hasPrimaryLocation W20009211921 @default.
- W2000921192 hasRelatedWork W1616226586 @default.
- W2000921192 hasRelatedWork W163455541 @default.
- W2000921192 hasRelatedWork W1951486303 @default.
- W2000921192 hasRelatedWork W1999615337 @default.
- W2000921192 hasRelatedWork W2045677033 @default.
- W2000921192 hasRelatedWork W2059269836 @default.
- W2000921192 hasRelatedWork W2077499328 @default.
- W2000921192 hasRelatedWork W2349378807 @default.
- W2000921192 hasRelatedWork W2350073883 @default.
- W2000921192 hasRelatedWork W2418536122 @default.
- W2000921192 hasVolume "86" @default.
- W2000921192 isParatext "false" @default.
- W2000921192 isRetracted "false" @default.
- W2000921192 magId "2000921192" @default.
- W2000921192 workType "article" @default.