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- W2000924162 abstract "Backgroundd-serine is an endogenous coagonist of the N-methyl-d-aspartate subtype glutamate receptor. Genetic association studies have implicated genes coding for enzymes associated with d-serine metabolism in schizophrenia and bipolar disorder.MethodsProtein expression of serine racemase (SR) and its binding partner, protein interacting with C-kinase (PICK1), were examined by Western blotting in brains from wildtype and PICK1 knockout mice. Levels of d-serine in wildtype and PICK1 mice were also examined by an established high-pressure liquid chromatography protocol.ResultsExpression of SR and PICK1 proteins was developmentally regulated. Although no change was observed in the level of SR protein, levels of d-serine were selectively decreased in the forebrain of neonatal PICK1 knockout mice, compared with those in wildtype mice.ConclusionsPICK1 may be involved in the regulation of brain d-serine levels and SR in a spatially and temporally specific manner. d-serine is an endogenous coagonist of the N-methyl-d-aspartate subtype glutamate receptor. Genetic association studies have implicated genes coding for enzymes associated with d-serine metabolism in schizophrenia and bipolar disorder. Protein expression of serine racemase (SR) and its binding partner, protein interacting with C-kinase (PICK1), were examined by Western blotting in brains from wildtype and PICK1 knockout mice. Levels of d-serine in wildtype and PICK1 mice were also examined by an established high-pressure liquid chromatography protocol. Expression of SR and PICK1 proteins was developmentally regulated. Although no change was observed in the level of SR protein, levels of d-serine were selectively decreased in the forebrain of neonatal PICK1 knockout mice, compared with those in wildtype mice. PICK1 may be involved in the regulation of brain d-serine levels and SR in a spatially and temporally specific manner." @default.
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- W2000924162 date "2008-05-01" @default.
- W2000924162 modified "2023-10-18" @default.
- W2000924162 title "Modulation of d-Serine Levels in Brains of Mice Lacking PICK1" @default.
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- W2000924162 doi "https://doi.org/10.1016/j.biopsych.2007.09.025" @default.
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