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- W2000924186 abstract "We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2–) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2–) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression." @default.
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- W2000924186 date "2004-05-01" @default.
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- W2000924186 title "TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines" @default.
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- W2000924186 doi "https://doi.org/10.1016/j.peptides.2003.11.023" @default.
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