Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000924725> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2000924725 endingPage "1046" @default.
- W2000924725 startingPage "1043" @default.
- W2000924725 abstract "Objective To determine how first trimester detection rates for Down's Syndrome vary with maternal age and to calculate the predictive value of an increased risk report at various maternal ages. Design Mathematical modelling of first trimester screening performance using fetal nuchal translucency and maternal serum free βhCG and pregnancy associated plasma protein‐A (PAPP‐A). Methods From within the Gaussian distributions of each marker in normal pregnancies and those affected by Down's Syndrome a series of 15,000 marker multiple of the medians were obtained for each group. These markers were then used to calculate the risks of Down's Syndrome using maternal ages ranging from 15 to 49 and the background risk of Down's Syndrome at each age. Using a 1 in 300 risk cutoff (at time of sampling) the false positive rate and detection rate was assessed at each year of maternal age. The predictive value of a positive result was calculated using Baye's theorem. Outcome measures False positive rates and detection rates at each year of maternal age between 15 and 49; the predictive value of a positive result for each maternal age between 15 and 49. Results At 15 years of age the detection rate was 77% at a 1.9% false positive rate, 84% at a 4% false positive rate at age 30, rising to 100% at a 67% false positive rate at age 49. The probability of Down's Syndrome once identified with an increased risk was 1:34 at 15 years, 1:29 at 30 years and 1:6 at 49 years. Conclusions As with second trimester biochemical screening, the detection rate and false positive rate vary considerably with age. However, detection rates across all ages are significantly higher than with second trimester screening. The risk of a positive screening result being a Down's pregnancy is considerably greater than with second trimester screening with an average probability of 1:29, compared with 1:55 in the second trimester. This information may be useful in counselling women with an increased risk result in first trimester screening." @default.
- W2000924725 created "2016-06-24" @default.
- W2000924725 creator A5075229954 @default.
- W2000924725 date "2001-10-01" @default.
- W2000924725 modified "2023-10-17" @default.
- W2000924725 title "Age related detection and false positive rates when screening for Down's Syndrome in the first trimester using fetal nuchal translucency and maternal serum free betahCG and PAPP-A" @default.
- W2000924725 cites W2093278388 @default.
- W2000924725 cites W2142091369 @default.
- W2000924725 cites W2147761948 @default.
- W2000924725 cites W2160730845 @default.
- W2000924725 cites W2314557130 @default.
- W2000924725 cites W2412527470 @default.
- W2000924725 cites W4230900352 @default.
- W2000924725 cites W4302402196 @default.
- W2000924725 doi "https://doi.org/10.1111/j.1471-0528.2001.00244.x" @default.
- W2000924725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11702835" @default.
- W2000924725 hasPublicationYear "2001" @default.
- W2000924725 type Work @default.
- W2000924725 sameAs 2000924725 @default.
- W2000924725 citedByCount "20" @default.
- W2000924725 countsByYear W20009247252012 @default.
- W2000924725 countsByYear W20009247252014 @default.
- W2000924725 countsByYear W20009247252015 @default.
- W2000924725 countsByYear W20009247252017 @default.
- W2000924725 countsByYear W20009247252019 @default.
- W2000924725 countsByYear W20009247252020 @default.
- W2000924725 countsByYear W20009247252022 @default.
- W2000924725 crossrefType "journal-article" @default.
- W2000924725 hasAuthorship W2000924725A5075229954 @default.
- W2000924725 hasConcept C105795698 @default.
- W2000924725 hasConcept C118552586 @default.
- W2000924725 hasConcept C121332964 @default.
- W2000924725 hasConcept C126322002 @default.
- W2000924725 hasConcept C131872663 @default.
- W2000924725 hasConcept C172680121 @default.
- W2000924725 hasConcept C198433322 @default.
- W2000924725 hasConcept C2778014424 @default.
- W2000924725 hasConcept C2778217198 @default.
- W2000924725 hasConcept C2778258057 @default.
- W2000924725 hasConcept C2779234561 @default.
- W2000924725 hasConcept C2779954681 @default.
- W2000924725 hasConcept C2909999348 @default.
- W2000924725 hasConcept C3019714739 @default.
- W2000924725 hasConcept C3019719930 @default.
- W2000924725 hasConcept C33923547 @default.
- W2000924725 hasConcept C54355233 @default.
- W2000924725 hasConcept C62520636 @default.
- W2000924725 hasConcept C71924100 @default.
- W2000924725 hasConcept C86803240 @default.
- W2000924725 hasConcept C95922358 @default.
- W2000924725 hasConceptScore W2000924725C105795698 @default.
- W2000924725 hasConceptScore W2000924725C118552586 @default.
- W2000924725 hasConceptScore W2000924725C121332964 @default.
- W2000924725 hasConceptScore W2000924725C126322002 @default.
- W2000924725 hasConceptScore W2000924725C131872663 @default.
- W2000924725 hasConceptScore W2000924725C172680121 @default.
- W2000924725 hasConceptScore W2000924725C198433322 @default.
- W2000924725 hasConceptScore W2000924725C2778014424 @default.
- W2000924725 hasConceptScore W2000924725C2778217198 @default.
- W2000924725 hasConceptScore W2000924725C2778258057 @default.
- W2000924725 hasConceptScore W2000924725C2779234561 @default.
- W2000924725 hasConceptScore W2000924725C2779954681 @default.
- W2000924725 hasConceptScore W2000924725C2909999348 @default.
- W2000924725 hasConceptScore W2000924725C3019714739 @default.
- W2000924725 hasConceptScore W2000924725C3019719930 @default.
- W2000924725 hasConceptScore W2000924725C33923547 @default.
- W2000924725 hasConceptScore W2000924725C54355233 @default.
- W2000924725 hasConceptScore W2000924725C62520636 @default.
- W2000924725 hasConceptScore W2000924725C71924100 @default.
- W2000924725 hasConceptScore W2000924725C86803240 @default.
- W2000924725 hasConceptScore W2000924725C95922358 @default.
- W2000924725 hasIssue "10" @default.
- W2000924725 hasLocation W20009247251 @default.
- W2000924725 hasLocation W20009247252 @default.
- W2000924725 hasOpenAccess W2000924725 @default.
- W2000924725 hasPrimaryLocation W20009247251 @default.
- W2000924725 hasRelatedWork W2000924725 @default.
- W2000924725 hasRelatedWork W2002440384 @default.
- W2000924725 hasRelatedWork W2046683525 @default.
- W2000924725 hasRelatedWork W2077492625 @default.
- W2000924725 hasRelatedWork W2089511039 @default.
- W2000924725 hasRelatedWork W2162325477 @default.
- W2000924725 hasRelatedWork W2224685743 @default.
- W2000924725 hasRelatedWork W4231099966 @default.
- W2000924725 hasRelatedWork W4239116640 @default.
- W2000924725 hasRelatedWork W4248367428 @default.
- W2000924725 hasVolume "108" @default.
- W2000924725 isParatext "false" @default.
- W2000924725 isRetracted "false" @default.
- W2000924725 magId "2000924725" @default.
- W2000924725 workType "article" @default.