FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000925162> ?p ?o ?g. }

• W2000925162 endingPage "27" @default.
• W2000925162 startingPage "18" @default.
• W2000925162 abstract "Because of the complexity and heterogeneity of human neuropsychiatric disorders, it has been difficult to identify animal models that mimic the symptoms of these neuropathologies and can be used to screen for antipsychotic agents. For this study we selected the murine 5HT2A/2C receptor agonist-induced head twitch response (HTR) induced by the administration of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), which has been proposed as an animal model of symptoms associated with a variety of behavioral and psychiatric conditions. We investigated the DOI-induced HTR in male DBA/2J mice using a panel of D2-like (D2, D3 and D4) and D2 dopamine receptor selective compounds. When DBA/2J mice were administered a daily dose of DOI (5 mg/kg), tolerance to the DOI occurs. However, administrations of the same dose of DOI every other day (48 h) or on a weekly basis did not lead to tolerance and the ability to induce tolerance after daily administration of DOI remains intact after repeated weekly administration of DOI. Subsequently, a panel of D2-like dopamine receptor antagonists was found to effectively inhibit the DOI-induced HTR in DBA/2J mice. However, the benzamide eticlopride, which is a high affinity D2-like antagonist, was a notable exception. SV 293, SV-III-130s and N-methylbenperidol, which exhibit a high affinity for D2 versus the D3 dopamine receptor subtypes (60- to 100-fold binding selectivity), were also found to inhibit the HTR in DBA/2J mice. This observation suggests a functional interaction between dopaminergic and serotonergic systems through D2 dopamine receptors and the 5-HT2A serotonin receptors in vivo." @default.
• W2000925162 created "2016-06-24" @default.
• W2000925162 creator A5013971949 @default.
• W2000925162 creator A5046107872 @default.
• W2000925162 creator A5059770390 @default.
• W2000925162 creator A5085597666 @default.
• W2000925162 creator A5090721546 @default.
• W2000925162 date "2014-08-01" @default.
• W2000925162 modified "2023-09-27" @default.
• W2000925162 title "Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds" @default.
• W2000925162 cites W1517802994 @default.
• W2000925162 cites W1895729847 @default.
• W2000925162 cites W1897852281 @default.
• W2000925162 cites W1967237555 @default.
• W2000925162 cites W1969553782 @default.
• W2000925162 cites W1969753516 @default.
• W2000925162 cites W1972931244 @default.
• W2000925162 cites W1974195654 @default.
• W2000925162 cites W1976729520 @default.
• W2000925162 cites W1980604666 @default.
• W2000925162 cites W1982522250 @default.
• W2000925162 cites W1982615078 @default.
• W2000925162 cites W1995694737 @default.
• W2000925162 cites W2000251979 @default.
• W2000925162 cites W2003772299 @default.
• W2000925162 cites W2008184625 @default.
• W2000925162 cites W2015870346 @default.
• W2000925162 cites W2016783203 @default.
• W2000925162 cites W2025678690 @default.
• W2000925162 cites W2027826213 @default.
• W2000925162 cites W2032996762 @default.
• W2000925162 cites W2040286544 @default.
• W2000925162 cites W2042570040 @default.
• W2000925162 cites W2042745003 @default.
• W2000925162 cites W2048184801 @default.
• W2000925162 cites W2054722815 @default.
• W2000925162 cites W2055633013 @default.
• W2000925162 cites W2057478907 @default.
• W2000925162 cites W2057913747 @default.
• W2000925162 cites W2063646581 @default.
• W2000925162 cites W2068825785 @default.
• W2000925162 cites W2070290419 @default.
• W2000925162 cites W2074631079 @default.
• W2000925162 cites W2075364609 @default.
• W2000925162 cites W2080123927 @default.
• W2000925162 cites W2099652807 @default.
• W2000925162 cites W2104844996 @default.
• W2000925162 cites W2125009546 @default.
• W2000925162 cites W2154878037 @default.
• W2000925162 cites W2161047862 @default.
• W2000925162 cites W2168216500 @default.
• W2000925162 cites W2172072650 @default.
• W2000925162 cites W2600960431 @default.
• W2000925162 cites W2809000008 @default.
• W2000925162 doi "https://doi.org/10.1016/j.neuropharm.2014.03.003" @default.
• W2000925162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24680675" @default.
• W2000925162 hasPublicationYear "2014" @default.
• W2000925162 type Work @default.
• W2000925162 sameAs 2000925162 @default.
• W2000925162 citedByCount "14" @default.
• W2000925162 countsByYear W20009251622014 @default.
• W2000925162 countsByYear W20009251622015 @default.
• W2000925162 countsByYear W20009251622016 @default.
• W2000925162 countsByYear W20009251622017 @default.
• W2000925162 countsByYear W20009251622018 @default.
• W2000925162 countsByYear W20009251622019 @default.
• W2000925162 countsByYear W20009251622020 @default.
• W2000925162 crossrefType "journal-article" @default.
• W2000925162 hasAuthorship W2000925162A5013971949 @default.
• W2000925162 hasAuthorship W2000925162A5046107872 @default.
• W2000925162 hasAuthorship W2000925162A5059770390 @default.
• W2000925162 hasAuthorship W2000925162A5085597666 @default.
• W2000925162 hasAuthorship W2000925162A5090721546 @default.
• W2000925162 hasConcept C120069818 @default.
• W2000925162 hasConcept C120750228 @default.
• W2000925162 hasConcept C126322002 @default.
• W2000925162 hasConcept C134018914 @default.
• W2000925162 hasConcept C137183658 @default.
• W2000925162 hasConcept C15744967 @default.
• W2000925162 hasConcept C170493617 @default.
• W2000925162 hasConcept C185592680 @default.
• W2000925162 hasConcept C199596767 @default.
• W2000925162 hasConcept C2776885963 @default.
• W2000925162 hasConcept C2778125517 @default.
• W2000925162 hasConcept C2778938600 @default.
• W2000925162 hasConcept C2779917531 @default.
• W2000925162 hasConcept C2780231548 @default.
• W2000925162 hasConcept C44208683 @default.
• W2000925162 hasConcept C513476851 @default.
• W2000925162 hasConcept C71240020 @default.
• W2000925162 hasConcept C71924100 @default.
• W2000925162 hasConcept C98274493 @default.
• W2000925162 hasConceptScore W2000925162C120069818 @default.
• W2000925162 hasConceptScore W2000925162C120750228 @default.
• W2000925162 hasConceptScore W2000925162C126322002 @default.
• W2000925162 hasConceptScore W2000925162C134018914 @default.
• W2000925162 hasConceptScore W2000925162C137183658 @default.
• W2000925162 hasConceptScore W2000925162C15744967 @default.

• next