FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000928189> ?p ?o ?g. }

• W2000928189 endingPage "14" @default.
• W2000928189 startingPage "3" @default.
• W2000928189 abstract "In prior studies form three centers, an exacerbation of obsessive-compulsive disorder (OCD) symptoms was reported in some (55%-83%) patients with OCD receiving the serotonergic agonist m-chlorophenylpiperazine (m-CPP) orally, whereas intravenously administered mCPP produced anxiety but no OCD symptom exacerbation. In the present replication attempt, 27 OCD patients were given mCPP either orally (n = 17) or intravenously (n = 10) under double-blind conditions, using identical behavioral rating measures. OCD symptoms were significantly increased after intravenous mCPP (0.1 mg/kg), but not after oral mCPP (0.5 mg/kg). Anxiety and other ratings were markedly elevated after intravenous mCPP administration. After oral mCPP administration, anxiety and most other self-ratings were only slightly elevated in comparison to placebo administration, and behavioral rating increases were no different for the OCD patients compared to age-matched healthy controls. Pretreatment with the potent serotonin (5-HT) antagonist, metergoline, prior to intravenous mCPP was associated with essentially complete blockade of the exacerbation in OCD symptoms and the other behavioral responses in the OCD patients. These results suggest that the behavioral response of OCD patients to mCPP are variable and depend on the route and dose of mCPP. In addition, the ability of metergoline to antagonize the behavioral effects of intravenous mCPP suggests that these responses are mediated by 5-HT1/5-HT2 receptors." @default.
• W2000928189 created "2016-06-24" @default.
• W2000928189 creator A5035335433 @default.
• W2000928189 creator A5055927135 @default.
• W2000928189 creator A5059061038 @default.
• W2000928189 creator A5063256213 @default.
• W2000928189 creator A5067921657 @default.
• W2000928189 creator A5069617316 @default.
• W2000928189 creator A5087025244 @default.
• W2000928189 date "1993-01-01" @default.
• W2000928189 modified "2023-09-27" @default.
• W2000928189 title "A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to IV mCPP" @default.
• W2000928189 cites W1975008955 @default.
• W2000928189 cites W1981665041 @default.
• W2000928189 cites W1982958152 @default.
• W2000928189 cites W1987266590 @default.
• W2000928189 cites W1992863880 @default.
• W2000928189 cites W1994627351 @default.
• W2000928189 cites W2005202278 @default.
• W2000928189 cites W2009821818 @default.
• W2000928189 cites W2019679136 @default.
• W2000928189 cites W2021546946 @default.
• W2000928189 cites W2029338703 @default.
• W2000928189 cites W2031769899 @default.
• W2000928189 cites W2033472966 @default.
• W2000928189 cites W2038361574 @default.
• W2000928189 cites W2041457090 @default.
• W2000928189 cites W2049807538 @default.
• W2000928189 cites W2054065030 @default.
• W2000928189 cites W2054194857 @default.
• W2000928189 cites W2065190583 @default.
• W2000928189 cites W2067160581 @default.
• W2000928189 cites W2067669670 @default.
• W2000928189 cites W2069837113 @default.
• W2000928189 cites W2070567675 @default.
• W2000928189 cites W2089868460 @default.
• W2000928189 cites W2092356890 @default.
• W2000928189 cites W2095378700 @default.
• W2000928189 cites W2147281759 @default.
• W2000928189 cites W2328859116 @default.
• W2000928189 cites W2345998241 @default.
• W2000928189 cites W4285139808 @default.
• W2000928189 cites W4361852032 @default.
• W2000928189 doi "https://doi.org/10.1016/0006-3223(93)90272-f" @default.
• W2000928189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8420593" @default.
• W2000928189 hasPublicationYear "1993" @default.
• W2000928189 type Work @default.
• W2000928189 sameAs 2000928189 @default.
• W2000928189 citedByCount "97" @default.
• W2000928189 countsByYear W20009281892012 @default.
• W2000928189 countsByYear W20009281892013 @default.
• W2000928189 countsByYear W20009281892014 @default.
• W2000928189 countsByYear W20009281892015 @default.
• W2000928189 countsByYear W20009281892016 @default.
• W2000928189 countsByYear W20009281892017 @default.
• W2000928189 countsByYear W20009281892018 @default.
• W2000928189 countsByYear W20009281892020 @default.
• W2000928189 countsByYear W20009281892022 @default.
• W2000928189 countsByYear W20009281892023 @default.
• W2000928189 crossrefType "journal-article" @default.
• W2000928189 hasAuthorship W2000928189A5035335433 @default.
• W2000928189 hasAuthorship W2000928189A5055927135 @default.
• W2000928189 hasAuthorship W2000928189A5059061038 @default.
• W2000928189 hasAuthorship W2000928189A5063256213 @default.
• W2000928189 hasAuthorship W2000928189A5067921657 @default.
• W2000928189 hasAuthorship W2000928189A5069617316 @default.
• W2000928189 hasAuthorship W2000928189A5087025244 @default.
• W2000928189 hasConcept C118552586 @default.
• W2000928189 hasConcept C126322002 @default.
• W2000928189 hasConcept C142724271 @default.
• W2000928189 hasConcept C15744967 @default.
• W2000928189 hasConcept C170493617 @default.
• W2000928189 hasConcept C204787440 @default.
• W2000928189 hasConcept C27081682 @default.
• W2000928189 hasConcept C2775864247 @default.
• W2000928189 hasConcept C2776120623 @default.
• W2000928189 hasConcept C2777014857 @default.
• W2000928189 hasConcept C2778938600 @default.
• W2000928189 hasConcept C2779177272 @default.
• W2000928189 hasConcept C2780980600 @default.
• W2000928189 hasConcept C37000724 @default.
• W2000928189 hasConcept C42219234 @default.
• W2000928189 hasConcept C558461103 @default.
• W2000928189 hasConcept C71924100 @default.
• W2000928189 hasConceptScore W2000928189C118552586 @default.
• W2000928189 hasConceptScore W2000928189C126322002 @default.
• W2000928189 hasConceptScore W2000928189C142724271 @default.
• W2000928189 hasConceptScore W2000928189C15744967 @default.
• W2000928189 hasConceptScore W2000928189C170493617 @default.
• W2000928189 hasConceptScore W2000928189C204787440 @default.
• W2000928189 hasConceptScore W2000928189C27081682 @default.
• W2000928189 hasConceptScore W2000928189C2775864247 @default.
• W2000928189 hasConceptScore W2000928189C2776120623 @default.
• W2000928189 hasConceptScore W2000928189C2777014857 @default.
• W2000928189 hasConceptScore W2000928189C2778938600 @default.
• W2000928189 hasConceptScore W2000928189C2779177272 @default.
• W2000928189 hasConceptScore W2000928189C2780980600 @default.
• W2000928189 hasConceptScore W2000928189C37000724 @default.

• next