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- W2000929237 abstract "The endothelial or epithelial tight junctions create a rate-limiting barrier to diffusion of solutes. A major determinant of the barrier function is the density of tight junction proteins. Since aging is associated with significant alterations in the blood–brain barrier (BBB) it is possible that specific tight junction proteins may be altered in the cerebrum of aging rats. To test this hypothesis, Western and Northern blot analysis were carried out to measure the steady-state level of occludin and zonula occludens-one (ZO-1) proteins and their mRNA in cerebral tissue of 3-, 12- and 24-month-old rats. The cerebral occludin content in 24-month-old rats (732.5±99.9 arbitrary units) was significantly reduced compared to 12-month-old rats (1043.4±131.8) or 3-month-old rats (1021.4±62.8), P<0.01. The cerebral ZO-1 protein content in 24-month-old rats (161.7±8.1 arbitrary units) and 12-month-old rats (144.3±35.9) were not significantly reduced compared to 4-month-old rats (189.0±27.2). The occludin mRNA content relative to G3PDH mRNA was 1.11±0.05, 1.11±0.07 and 1.00±0.05 in 3-, 12- and 24-month-old rats, respectively. The differences did not achieve statistical significance. The ZO-1 mRNA content of cerebral tissue relative to G3PDH mRNA was significantly increased in 24-month-old rats compared to 3-month-old rats (1.280±0.030 vs. 0.956±0.038), P<0.001. It is concluded that aging in rats may alter the molecular anatomy of the BBB by altering the content of select structural proteins of tight junctions." @default.
- W2000929237 created "2016-06-24" @default.
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- W2000929237 date "2003-02-01" @default.
- W2000929237 modified "2023-09-23" @default.
- W2000929237 title "Age-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1)" @default.
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- W2000929237 doi "https://doi.org/10.1016/s0047-6374(02)00041-6" @default.
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