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- W2000930260 abstract "A new oxaliplatin analog [Pt(dach)(L5)] ( 1 ) was synthesized and characterized as a continuation of a study of the previously reported [Pt(dach)(L6)] ( 2 ), where dach = (1 R ,2 R )-diaminocyclohexane, L5 = 3-carboxyboldine, and L6 = 3-carboxypredicentrine. Compounds 1 and 2 exhibited a substantially enhanced antioxidant activity compared to oxaliplatin (130 and 30 times for 1 and 13 and 4 times for 2 using the DPPH and FRAP assays, resp.). In addition, 1 and 2 exhibited cytotoxic activity in the same range as oxaliplatin toward the two human tumor cell lines (MCF-7 and HT-29) studied and two to four times lower activity in the human colon nontumor cell line (CCD-841). Preadministration of L5 or L6 to the colon tumor (HT-29) and the colon nontumor (CCD-841) cell lines prior to oxaliplatin addition increased the viability of the nontumor cell line to a greater extent than that of the tumor cell line." @default.
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- W2000930260 date "2015-01-01" @default.
- W2000930260 modified "2023-10-16" @default.
- W2000930260 title "Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity" @default.
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- W2000930260 doi "https://doi.org/10.1155/2015/920143" @default.
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