FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000931407> ?p ?o ?g. }

• W2000931407 endingPage "614" @default.
• W2000931407 startingPage "610" @default.
• W2000931407 abstract "Background and Purpose —Clot dissolution with tissue plasminogen activator (tPA) can lead to early clinical recovery after stroke. Transcranial Doppler (TCD) with low MHz frequency can determine arterial occlusion and monitor recanalization and may potentiate thrombolysis. Methods —Stroke patients receiving intravenous tPA were monitored during infusion with portable TCD (Multigon 500M; DWL MultiDop-T) and headframe (Marc series; Spencer Technologies). Residual flow signals were obtained from the clot location identified by TCD. National Institutes of Health Stroke Scale (NIHSS) scores were obtained before and after tPA infusion. Results —Forty patients were studied (mean age 70±16 years, baseline NIHSS score 18.6±6.2, tPA bolus at 132±54 minutes from symptom onset). TCD monitoring started at 125±52 minutes and continued for the duration of tPA infusion. The middle cerebral artery was occluded in 30 patients, the internal carotid artery was occluded in 11 patients, the basilar artery was occluded in 3 patients, and occlusions were multiple in 7 patients; 4 patients had no windows; and 1 patient had a normal TCD. Recanalization on TCD was found at 45±20 minutes after tPA bolus: recanalization was complete in 12 (30%) and partial in 16 (40%) patients. Dramatic recovery during tPA infusion (total NIHSS score <3) occurred in 8 (20%) of all patients (baseline NIHSS range 6 to 22; all 8 had complete recanalization). Lack of improvement or worsening was associated with no recanalization, late recanalization, or reocclusion on TCD (C=0.811, P ≤0.01). Improvement by ≥10 NIHSS points or complete recovery was found in 30% of all patients at the end of tPA infusion and in 40% at 24 hours. Improvement by ≥4 NIHSS points was found in 62.5% of patients at 24 hours. Conclusions —Dramatic recovery during tPA therapy occurred in 20% of all patients when infusion was continuously monitored with TCD. Recovery was associated with recanalization on TCD, whereas no early improvement indicated persistent occlusion or reocclusion. At 24 hours, 40% of all patients improved by ≥10 NIHSS points or recovered completely. Ultrasonic energy transmission by TCD monitoring may expose more clot surface to tPA and facilitate thrombolysis and deserves a controlled trial as a way to potentiate the effect of tPA therapy." @default.
• W2000931407 created "2016-06-24" @default.
• W2000931407 creator A5033438689 @default.
• W2000931407 date "2000-03-01" @default.
• W2000931407 modified "2023-09-30" @default.
• W2000931407 title "High Rate of Complete Recanalization and Dramatic Clinical Recovery During tPA Infusion When Continuously Monitored With 2-MHz Transcranial Doppler Monitoring" @default.
• W2000931407 cites W1989985571 @default.
• W2000931407 cites W2002927050 @default.
• W2000931407 cites W2032953600 @default.
• W2000931407 cites W2040120906 @default.
• W2000931407 cites W2080431174 @default.
• W2000931407 cites W2118738743 @default.
• W2000931407 cites W2125955807 @default.
• W2000931407 cites W2157523095 @default.
• W2000931407 cites W2292308933 @default.
• W2000931407 cites W2330752745 @default.
• W2000931407 cites W2337100493 @default.
• W2000931407 doi "https://doi.org/10.1161/01.str.31.3.610" @default.
• W2000931407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11108775" @default.
• W2000931407 hasPublicationYear "2000" @default.
• W2000931407 type Work @default.
• W2000931407 sameAs 2000931407 @default.
• W2000931407 citedByCount "298" @default.
• W2000931407 countsByYear W20009314072012 @default.
• W2000931407 countsByYear W20009314072013 @default.
• W2000931407 countsByYear W20009314072014 @default.
• W2000931407 countsByYear W20009314072015 @default.
• W2000931407 countsByYear W20009314072016 @default.
• W2000931407 countsByYear W20009314072017 @default.
• W2000931407 countsByYear W20009314072018 @default.
• W2000931407 countsByYear W20009314072019 @default.
• W2000931407 countsByYear W20009314072020 @default.
• W2000931407 countsByYear W20009314072021 @default.
• W2000931407 countsByYear W20009314072022 @default.
• W2000931407 crossrefType "journal-article" @default.
• W2000931407 hasAuthorship W2000931407A5033438689 @default.
• W2000931407 hasBestOaLocation W20009314071 @default.
• W2000931407 hasConcept C126322002 @default.
• W2000931407 hasConcept C127413603 @default.
• W2000931407 hasConcept C141071460 @default.
• W2000931407 hasConcept C164705383 @default.
• W2000931407 hasConcept C191616109 @default.
• W2000931407 hasConcept C2775841333 @default.
• W2000931407 hasConcept C2776268601 @default.
• W2000931407 hasConcept C2776572282 @default.
• W2000931407 hasConcept C2778333808 @default.
• W2000931407 hasConcept C2779581417 @default.
• W2000931407 hasConcept C2780645631 @default.
• W2000931407 hasConcept C2781012200 @default.
• W2000931407 hasConcept C2909817843 @default.
• W2000931407 hasConcept C42219234 @default.
• W2000931407 hasConcept C43376680 @default.
• W2000931407 hasConcept C500558357 @default.
• W2000931407 hasConcept C541997718 @default.
• W2000931407 hasConcept C71924100 @default.
• W2000931407 hasConcept C78519656 @default.
• W2000931407 hasConceptScore W2000931407C126322002 @default.
• W2000931407 hasConceptScore W2000931407C127413603 @default.
• W2000931407 hasConceptScore W2000931407C141071460 @default.
• W2000931407 hasConceptScore W2000931407C164705383 @default.
• W2000931407 hasConceptScore W2000931407C191616109 @default.
• W2000931407 hasConceptScore W2000931407C2775841333 @default.
• W2000931407 hasConceptScore W2000931407C2776268601 @default.
• W2000931407 hasConceptScore W2000931407C2776572282 @default.
• W2000931407 hasConceptScore W2000931407C2778333808 @default.
• W2000931407 hasConceptScore W2000931407C2779581417 @default.
• W2000931407 hasConceptScore W2000931407C2780645631 @default.
• W2000931407 hasConceptScore W2000931407C2781012200 @default.
• W2000931407 hasConceptScore W2000931407C2909817843 @default.
• W2000931407 hasConceptScore W2000931407C42219234 @default.
• W2000931407 hasConceptScore W2000931407C43376680 @default.
• W2000931407 hasConceptScore W2000931407C500558357 @default.
• W2000931407 hasConceptScore W2000931407C541997718 @default.
• W2000931407 hasConceptScore W2000931407C71924100 @default.
• W2000931407 hasConceptScore W2000931407C78519656 @default.
• W2000931407 hasIssue "3" @default.
• W2000931407 hasLocation W20009314071 @default.
• W2000931407 hasLocation W20009314072 @default.
• W2000931407 hasOpenAccess W2000931407 @default.
• W2000931407 hasPrimaryLocation W20009314071 @default.
• W2000931407 hasRelatedWork W1739587499 @default.
• W2000931407 hasRelatedWork W1956511422 @default.
• W2000931407 hasRelatedWork W1977297508 @default.
• W2000931407 hasRelatedWork W2089505196 @default.
• W2000931407 hasRelatedWork W2101105099 @default.
• W2000931407 hasRelatedWork W2144716609 @default.
• W2000931407 hasRelatedWork W2145722221 @default.
• W2000931407 hasRelatedWork W2153057483 @default.
• W2000931407 hasRelatedWork W2382341956 @default.
• W2000931407 hasRelatedWork W4229535724 @default.
• W2000931407 hasVolume "31" @default.
• W2000931407 isParatext "false" @default.
• W2000931407 isRetracted "false" @default.
• W2000931407 magId "2000931407" @default.
• W2000931407 workType "article" @default.