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- W2000931431 abstract "Open label and single blinded randomized controlled clinical trials are vulnerable to selection bias when the next treatment assignment is predictable based on the randomization algorithm and the preceding assignment history. While treatment predictability is an issue for all constrained randomization algorithms, deterministic assignments are unique to permuted block randomization. Deterministic assignments may lead to treatment predictability with certainty and selection bias, which could inflate the type I error and hurts the validity of trial results. It is important to accurately evaluate the probability of deterministic assignments in permuted block randomization, so proper protection measures can be implemented. For trials with number of treatment arms T=2 and a balance block size B=2m, Matts and Lachin indicated that the probability of deterministic assignment is 1/(m+1). For more general situations, with T≥2 and a block size B=∑j=1Tmj, Dupin-Spriet provided a formula, which can be written as (1/B)∑j=1T∑i=1mj∏k=1i(mj−k+1)/(B−k+1). This formula involves extensive calculation in evaluation. In this paper, we simplified this formula to (1/B)∑j=1Tmj/(B−mj+1) for general scenarios and 1/(B−m+1) for trials with a balanced allocation. Through mathematical induction we show the equivalence of the formulas. While the new formula is numerically equivalent to Dupin-Spriet’s formula, the simple format not only is easier for evaluation, but also is clearer in describing the impact of parameters T and mi on the probability of deterministic assignments." @default.
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- W2000931431 date "1986-09-01" @default.
- W2000931431 modified "2023-09-24" @default.
- W2000931431 title "Analysis of recurrent events based on random interval count data" @default.
- W2000931431 doi "https://doi.org/10.1016/0197-2456(86)90079-6" @default.
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