FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000931591> ?p ?o ?g. }

• W2000931591 endingPage "e430" @default.
• W2000931591 startingPage "e430" @default.
• W2000931591 abstract "Molecular abnormalities in metabolic, hormonal and immune pathways are present in peripheral body fluids of a significant subgroup of schizophrenia patients. The authors have tested whether such disturbances also occur in psychiatrically ill and unaffected siblings of schizophrenia patients with the aim of identifying potential contributing factors to disease vulnerability. The subjects were recruited as part of the Genetic Risk and OUtcome of Psychosis (GROUP) study. The authors used multiplexed immunoassays to measure the levels of 184 molecules in serum from 112 schizophrenia patients, 133 siblings and 87 unrelated controls. Consistent with the findings of previous studies, serum from schizophrenia patients contained higher levels of insulin, C-peptide and proinsulin, decreased levels of growth hormone and altered concentrations of molecules involved in inflammation. In addition, significant differences were found in the levels of some of these proteins in siblings diagnosed with mood disorders (n=16) and in unaffected siblings (n=117). Most significantly, the insulin/growth hormone ratio was higher across all groups compared with the controls. Taken together, these findings suggest the presence of a molecular endophenotype involving disruption of insulin and growth factor signaling pathways as an increased risk factor for schizophrenia." @default.
• W2000931591 created "2016-06-24" @default.
• W2000931591 creator A5012919903 @default.
• W2000931591 creator A5018639419 @default.
• W2000931591 creator A5019797607 @default.
• W2000931591 creator A5037303532 @default.
• W2000931591 creator A5049205174 @default.
• W2000931591 creator A5059529807 @default.
• W2000931591 creator A5064181236 @default.
• W2000931591 date "2014-08-26" @default.
• W2000931591 modified "2023-10-06" @default.
• W2000931591 title "Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia" @default.
• W2000931591 cites W121109719 @default.
• W2000931591 cites W1901547630 @default.
• W2000931591 cites W1946774659 @default.
• W2000931591 cites W1975846239 @default.
• W2000931591 cites W1978876811 @default.
• W2000931591 cites W1987857702 @default.
• W2000931591 cites W1990126854 @default.
• W2000931591 cites W1990208139 @default.
• W2000931591 cites W2000102453 @default.
• W2000931591 cites W2004340733 @default.
• W2000931591 cites W2005445084 @default.
• W2000931591 cites W2007353040 @default.
• W2000931591 cites W2015413496 @default.
• W2000931591 cites W2018699892 @default.
• W2000931591 cites W2019145385 @default.
• W2000931591 cites W2024140630 @default.
• W2000931591 cites W2024621431 @default.
• W2000931591 cites W2042559950 @default.
• W2000931591 cites W2043676311 @default.
• W2000931591 cites W2044425469 @default.
• W2000931591 cites W2052998051 @default.
• W2000931591 cites W2055081835 @default.
• W2000931591 cites W2057251357 @default.
• W2000931591 cites W2060152590 @default.
• W2000931591 cites W2075650547 @default.
• W2000931591 cites W2076479521 @default.
• W2000931591 cites W2076818959 @default.
• W2000931591 cites W2084002557 @default.
• W2000931591 cites W2086650946 @default.
• W2000931591 cites W2101971272 @default.
• W2000931591 cites W2119362484 @default.
• W2000931591 cites W2123879827 @default.
• W2000931591 cites W2124054528 @default.
• W2000931591 cites W2132554694 @default.
• W2000931591 cites W2137102585 @default.
• W2000931591 cites W2140606211 @default.
• W2000931591 cites W2142423573 @default.
• W2000931591 cites W2149173020 @default.
• W2000931591 cites W2157476554 @default.
• W2000931591 cites W2168408561 @default.
• W2000931591 cites W2170585266 @default.
• W2000931591 doi "https://doi.org/10.1038/tp.2014.52" @default.
• W2000931591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4150237" @default.
• W2000931591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25158005" @default.
• W2000931591 hasPublicationYear "2014" @default.
• W2000931591 type Work @default.
• W2000931591 sameAs 2000931591 @default.
• W2000931591 citedByCount "35" @default.
• W2000931591 countsByYear W20009315912015 @default.
• W2000931591 countsByYear W20009315912016 @default.
• W2000931591 countsByYear W20009315912017 @default.
• W2000931591 countsByYear W20009315912018 @default.
• W2000931591 countsByYear W20009315912019 @default.
• W2000931591 countsByYear W20009315912020 @default.
• W2000931591 countsByYear W20009315912021 @default.
• W2000931591 countsByYear W20009315912022 @default.
• W2000931591 countsByYear W20009315912023 @default.
• W2000931591 crossrefType "journal-article" @default.
• W2000931591 hasAuthorship W2000931591A5012919903 @default.
• W2000931591 hasAuthorship W2000931591A5018639419 @default.
• W2000931591 hasAuthorship W2000931591A5019797607 @default.
• W2000931591 hasAuthorship W2000931591A5037303532 @default.
• W2000931591 hasAuthorship W2000931591A5049205174 @default.
• W2000931591 hasAuthorship W2000931591A5059529807 @default.
• W2000931591 hasAuthorship W2000931591A5064181236 @default.
• W2000931591 hasBestOaLocation W20009315911 @default.
• W2000931591 hasConcept C118552586 @default.
• W2000931591 hasConcept C126322002 @default.
• W2000931591 hasConcept C134018914 @default.
• W2000931591 hasConcept C15744967 @default.
• W2000931591 hasConcept C169900460 @default.
• W2000931591 hasConcept C170493617 @default.
• W2000931591 hasConcept C187869287 @default.
• W2000931591 hasConcept C2775960820 @default.
• W2000931591 hasConcept C2776412080 @default.
• W2000931591 hasConcept C2777134132 @default.
• W2000931591 hasConcept C2779306644 @default.
• W2000931591 hasConcept C2779727114 @default.
• W2000931591 hasConcept C2780689927 @default.
• W2000931591 hasConcept C2780733359 @default.
• W2000931591 hasConcept C50440223 @default.
• W2000931591 hasConcept C558461103 @default.
• W2000931591 hasConcept C71315377 @default.
• W2000931591 hasConcept C71924100 @default.
• W2000931591 hasConcept C90061646 @default.
• W2000931591 hasConceptScore W2000931591C118552586 @default.

• next