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- W2000934426 abstract "Abstract Objective To assess whether therapy with two widely used antidepressants influences platelet counts. Subjects and methods In 90 patients hospitalized for treatment of a major depressive episode according to DSM-IV, platelet counts were performed after a 6 d antidepressant-free run-in period and again after 35 d of active standardized treatment with amitriptyline ( n = 40) or paroxetine ( n = 50). Results There was a trend for platelet counts to increase during treatment with amitriptyline (from 245.5 ± 68.6 to 256.8 ± 69 cells × 10 9 L -1 , P < 0.06); no change was observed during treatment with paroxetine (from 232.6 ± 58.3 to 234.6 ± 68.9 cells × 10 9 L -1 , n.s). Conclusions Treatment with amitriptyline tends to be associated with elevated platelet counts. The cause for this increase is not known, but may be relevant in terms of patients’ long-term thromboembolic risk." @default.
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- W2000934426 date "2003-03-01" @default.
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- W2000934426 title "Platelet counts in depressed patients treated with amitriptyline or paroxetine" @default.
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- W2000934426 doi "https://doi.org/10.1016/s0924-9338(03)00006-3" @default.
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