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• W2000934711 abstract "Biological processes are not exempt from errors and RNA production is not an exception to this rule. Errors can arise stochastically or be genetically fixed and systematically appear in the biochemical or cellular phenotype. In any case, quality control mechanisms are essential to minimize the potentially toxic effects of faulty RNA production or processing. Although many RNA molecules express their functional potential in the cytoplasm, as messengers, adaptors or operators of gene expression pathways, a large share of quality control occurs in the nucleus. This is likely because the early timing of occurrence and the subcellular partition make the control more efficient, at least as long as the defects can be detected ahead of the cytoplasmic phase of the RNA life cycle. One crucial point in discussing RNA quality control resides in its definition. A stringent take would imply the existence of specific mechanisms to recognize the error and the consequent repair or elimination of the faulty molecule. One example in the RNA field could be the recognition of a premature stop codon by the nonsense-mediated decay pathway, discussed elsewhere in this issue. A more relaxed view posits that the thermodynamic or kinetic aftermath of a mistake (e.g. a blockage or a delay in processing) by itself constitutes the recognition event, which triggers downstream quality control. Because whether inappropriate molecules are specifically recognized remains unclear in many cases, we will adopt the more relaxed definition of RNA quality control. RNA repair remains episodic and the degradative elimination of crippled molecules appears to be the rule. Therefore we will briefly describe the actors of RNA degradation in the nucleus. Detailed analyses of the mechanism of action of these enzymes can be found in several excellent and recent reviews, including in this issue. Finally, we will restrict our analysis to the yeast model, which is used in the majority of RNA quality control studies, but examples exist in the literature indicating that many of the principles of RNA quality control described in yeast also apply to other eukaryotes. This article is part of a Special Issue entitled: RNA Decay mechanisms." @default.
• W2000934711 created "2016-06-24" @default.
• W2000934711 creator A5046790624 @default.
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• W2000934711 date "2013-06-01" @default.
• W2000934711 modified "2023-09-25" @default.
• W2000934711 title "RNA quality control in the nucleus: The Angels' share of RNA" @default.
• W2000934711 cites W1963504189 @default.
• W2000934711 cites W1963604994 @default.
• W2000934711 cites W1965579368 @default.
• W2000934711 cites W1969840430 @default.
• W2000934711 cites W1976144735 @default.
• W2000934711 cites W1979277911 @default.
• W2000934711 cites W1986011347 @default.
• W2000934711 cites W1987777159 @default.
• W2000934711 cites W1988309554 @default.
• W2000934711 cites W1989653036 @default.
• W2000934711 cites W1991191643 @default.
• W2000934711 cites W1991554118 @default.
• W2000934711 cites W1992433724 @default.
• W2000934711 cites W1994886301 @default.
• W2000934711 cites W1995481648 @default.
• W2000934711 cites W1995842607 @default.
• W2000934711 cites W2000153470 @default.
• W2000934711 cites W2007982521 @default.
• W2000934711 cites W2008616402 @default.
• W2000934711 cites W2012466702 @default.
• W2000934711 cites W2013947447 @default.
• W2000934711 cites W2014242307 @default.
• W2000934711 cites W2015298553 @default.
• W2000934711 cites W2019379779 @default.
• W2000934711 cites W2021314556 @default.
• W2000934711 cites W2023407829 @default.
• W2000934711 cites W2028061670 @default.
• W2000934711 cites W2032501207 @default.
• W2000934711 cites W2032742580 @default.
• W2000934711 cites W2034490095 @default.
• W2000934711 cites W2035792284 @default.
• W2000934711 cites W2037451497 @default.
• W2000934711 cites W2038424676 @default.
• W2000934711 cites W2040010148 @default.
• W2000934711 cites W2040367656 @default.
• W2000934711 cites W2052606860 @default.
• W2000934711 cites W2056586488 @default.
• W2000934711 cites W2067466498 @default.
• W2000934711 cites W2067584429 @default.
• W2000934711 cites W2072879155 @default.
• W2000934711 cites W2079493448 @default.
• W2000934711 cites W2087342333 @default.
• W2000934711 cites W2087920243 @default.
• W2000934711 cites W2088722891 @default.
• W2000934711 cites W2089004878 @default.
• W2000934711 cites W2090850551 @default.
• W2000934711 cites W2091297785 @default.
• W2000934711 cites W2100041522 @default.
• W2000934711 cites W2101559095 @default.
• W2000934711 cites W2103724315 @default.
• W2000934711 cites W2106601322 @default.
• W2000934711 cites W2108143895 @default.
• W2000934711 cites W2110544609 @default.
• W2000934711 cites W2110621117 @default.
• W2000934711 cites W2114245651 @default.
• W2000934711 cites W2116892066 @default.
• W2000934711 cites W2118929024 @default.
• W2000934711 cites W2120818838 @default.
• W2000934711 cites W2121169843 @default.
• W2000934711 cites W2123114975 @default.
• W2000934711 cites W2132315340 @default.
• W2000934711 cites W2137557128 @default.
• W2000934711 cites W2141803636 @default.
• W2000934711 cites W2144414956 @default.
• W2000934711 cites W2149681259 @default.
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• W2000934711 cites W2163805932 @default.
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• W2000934711 doi "https://doi.org/10.1016/j.bbagrm.2013.02.012" @default.
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