Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000934747> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2000934747 endingPage "393" @default.
- W2000934747 startingPage "387" @default.
- W2000934747 abstract "Raltegravir was the first licensed integrase inhibitor. Real-life experience is informative and complements trial data. We therefore evaluated raltegravir use in adults in a large HIV treatment centre. From pharmacy and departmental HIV database records, we identified all adults taking ≥1 dose of raltegravir from first availability to the end of November 2012. Data were collected using a standardised case report form. Two hundred and fifteen individuals provided 502 patient-years (median 2.6 years/person) of raltegravir use. Of 215 individuals, 166 (77%) were male, median age 43 years; 189 (88%) were antiretroviral therapy (ART)-experienced and 26 (12%) ART-naive, with median baseline CD4 counts of 324 and 54 cells/µL, respectively. Of ten individuals using once-daily raltegravir, four, with good adherence remained virologically suppressed after a median 28 months, four stopped against medical advice, one stopped to simplify and one failed virologically. In hepatitis co-infection, 35 individuals (92 patient-years) took raltegravir without evidence of hepatotoxicity. Six women started raltegravir during pregnancy for intensification (5/6) or switch for tolerability without complications. Of ten individuals stopping raltegravir after virological failure, 2/4 with successful sequencing showed resistance. Raltegravir appears safe and effective, without evidence of toxicity above that in published trials, including in pregnancy and co-infections. Once-daily dosing seems effective where adherence is good." @default.
- W2000934747 created "2016-06-24" @default.
- W2000934747 creator A5002152360 @default.
- W2000934747 creator A5018843039 @default.
- W2000934747 creator A5046324949 @default.
- W2000934747 creator A5053194228 @default.
- W2000934747 creator A5056002767 @default.
- W2000934747 creator A5078170556 @default.
- W2000934747 date "2015-04-29" @default.
- W2000934747 modified "2023-10-16" @default.
- W2000934747 title "Five years’ real-life experience with raltegravir in a large HIV centre" @default.
- W2000934747 cites W1494975826 @default.
- W2000934747 cites W1571027354 @default.
- W2000934747 cites W1940662020 @default.
- W2000934747 cites W1988062692 @default.
- W2000934747 cites W1995068286 @default.
- W2000934747 cites W2062440277 @default.
- W2000934747 cites W2087194479 @default.
- W2000934747 cites W2098175901 @default.
- W2000934747 cites W2100511907 @default.
- W2000934747 cites W2116146956 @default.
- W2000934747 cites W2117261241 @default.
- W2000934747 doi "https://doi.org/10.1177/0956462415584485" @default.
- W2000934747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25931236" @default.
- W2000934747 hasPublicationYear "2015" @default.
- W2000934747 type Work @default.
- W2000934747 sameAs 2000934747 @default.
- W2000934747 citedByCount "9" @default.
- W2000934747 countsByYear W20009347472016 @default.
- W2000934747 countsByYear W20009347472017 @default.
- W2000934747 countsByYear W20009347472018 @default.
- W2000934747 countsByYear W20009347472020 @default.
- W2000934747 countsByYear W20009347472023 @default.
- W2000934747 crossrefType "journal-article" @default.
- W2000934747 hasAuthorship W2000934747A5002152360 @default.
- W2000934747 hasAuthorship W2000934747A5018843039 @default.
- W2000934747 hasAuthorship W2000934747A5046324949 @default.
- W2000934747 hasAuthorship W2000934747A5053194228 @default.
- W2000934747 hasAuthorship W2000934747A5056002767 @default.
- W2000934747 hasAuthorship W2000934747A5078170556 @default.
- W2000934747 hasConcept C104863432 @default.
- W2000934747 hasConcept C126322002 @default.
- W2000934747 hasConcept C142462285 @default.
- W2000934747 hasConcept C159047783 @default.
- W2000934747 hasConcept C197934379 @default.
- W2000934747 hasConcept C2777302000 @default.
- W2000934747 hasConcept C2778375690 @default.
- W2000934747 hasConcept C2779502633 @default.
- W2000934747 hasConcept C2780404665 @default.
- W2000934747 hasConcept C2993143319 @default.
- W2000934747 hasConcept C3013748606 @default.
- W2000934747 hasConcept C512399662 @default.
- W2000934747 hasConcept C71924100 @default.
- W2000934747 hasConceptScore W2000934747C104863432 @default.
- W2000934747 hasConceptScore W2000934747C126322002 @default.
- W2000934747 hasConceptScore W2000934747C142462285 @default.
- W2000934747 hasConceptScore W2000934747C159047783 @default.
- W2000934747 hasConceptScore W2000934747C197934379 @default.
- W2000934747 hasConceptScore W2000934747C2777302000 @default.
- W2000934747 hasConceptScore W2000934747C2778375690 @default.
- W2000934747 hasConceptScore W2000934747C2779502633 @default.
- W2000934747 hasConceptScore W2000934747C2780404665 @default.
- W2000934747 hasConceptScore W2000934747C2993143319 @default.
- W2000934747 hasConceptScore W2000934747C3013748606 @default.
- W2000934747 hasConceptScore W2000934747C512399662 @default.
- W2000934747 hasConceptScore W2000934747C71924100 @default.
- W2000934747 hasIssue "5" @default.
- W2000934747 hasLocation W20009347471 @default.
- W2000934747 hasLocation W20009347472 @default.
- W2000934747 hasOpenAccess W2000934747 @default.
- W2000934747 hasPrimaryLocation W20009347471 @default.
- W2000934747 hasRelatedWork W2068448856 @default.
- W2000934747 hasRelatedWork W2077998490 @default.
- W2000934747 hasRelatedWork W2101998560 @default.
- W2000934747 hasRelatedWork W2140123055 @default.
- W2000934747 hasRelatedWork W2392594014 @default.
- W2000934747 hasRelatedWork W2474869173 @default.
- W2000934747 hasRelatedWork W2600834309 @default.
- W2000934747 hasRelatedWork W2626729825 @default.
- W2000934747 hasRelatedWork W2747838037 @default.
- W2000934747 hasRelatedWork W2797646691 @default.
- W2000934747 hasVolume "27" @default.
- W2000934747 isParatext "false" @default.
- W2000934747 isRetracted "false" @default.
- W2000934747 magId "2000934747" @default.
- W2000934747 workType "article" @default.