FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000934782> ?p ?o ?g. }

• W2000934782 endingPage "238" @default.
• W2000934782 startingPage "230" @default.
• W2000934782 abstract "Studies were carried out to examine the effects of and interactions between NADPH, Fe2+, Fe3+ and ascorbate on lipid peroxidation in guinea-pig adrenal microsomes. Fe2+, at levels between 10−6 and 10−3 M, produced concentration-dependent increases in lipid peroxidation in adrenal microsomes; Fe2+ had a far greater effect than Fe3+. In liver microsomes, by contrast, Fe2+ and Fe3+ had quantitatively similar effects on lipid peroxidation. NADPH alone had no effect on malonaldehyde production by adrenal microsomes. However, in the presence of low Fe2+ concentrations (10−6 M), NADPH stimulated malonaldehyde production; the stimulation was not demonstrable in microsomes which had been heat-treated to inactive microsomal enzymes. In the presence of high Fe2+ levels (10−3 M), NADPH produced a concentration-dependent inhibition of lipid peroxidation; the inhibition was fully demonstrable in heat-treated microsomes. In the presence of Fe3+ (10−6 to 10−3 M), NADPH had little effect on lipid peroxidation, suggesting that NADPH does not significantly promote the reduction of Fe3+ to Fe2+ in adrenal microsomes. Ascorbate alone increased malonaldehyde production by adrenal microsomes; maximum stimulation occurred at a concentration of 10−4 M. Ascorbate-induced lipid peroxidation was also inhibited by NADPH. Ascorbate (5 · 10−6 to 1 · 10−4 M) synergistically interacted with low levels (10−6 M) of Fe2+ to enhance malonaldehyde production by adrenal microsomes. The synergism was not demonstrable at high concentrations (10−3 M) of Fe2+ At all concentrations (10−6 to 10−3 M) of Fe3+ studied, ascorbate synergistically increased the production of malonaldehyde. The results indicate that interactions between various endogenous substances may be important in the control of adrenal microsomal lipid peroxidation and that there are differences in the regulation of adrenal and hepatic lipid peroxidation." @default.
• W2000934782 created "2016-06-24" @default.
• W2000934782 creator A5020168034 @default.
• W2000934782 creator A5023613168 @default.
• W2000934782 creator A5031891304 @default.
• W2000934782 date "1981-01-01" @default.
• W2000934782 modified "2023-09-27" @default.
• W2000934782 title "Factors affecting lipid peroxidation in guinea-pig adrenal microsomes" @default.
• W2000934782 cites W1488511002 @default.
• W2000934782 cites W1643379906 @default.
• W2000934782 cites W1806194750 @default.
• W2000934782 cites W1846762578 @default.
• W2000934782 cites W18546601 @default.
• W2000934782 cites W1903873355 @default.
• W2000934782 cites W1969982879 @default.
• W2000934782 cites W1975748676 @default.
• W2000934782 cites W1988948537 @default.
• W2000934782 cites W2001510074 @default.
• W2000934782 cites W2003614934 @default.
• W2000934782 cites W2006564336 @default.
• W2000934782 cites W2014550587 @default.
• W2000934782 cites W2025259897 @default.
• W2000934782 cites W2044559504 @default.
• W2000934782 cites W2069655299 @default.
• W2000934782 cites W2071877828 @default.
• W2000934782 cites W2088027567 @default.
• W2000934782 cites W2090292893 @default.
• W2000934782 cites W2094128088 @default.
• W2000934782 cites W2153060852 @default.
• W2000934782 cites W2174673748 @default.
• W2000934782 cites W83793659 @default.
• W2000934782 doi "https://doi.org/10.1016/0005-2760(81)90209-5" @default.
• W2000934782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7213766" @default.
• W2000934782 hasPublicationYear "1981" @default.
• W2000934782 type Work @default.
• W2000934782 sameAs 2000934782 @default.
• W2000934782 citedByCount "10" @default.
• W2000934782 crossrefType "journal-article" @default.
• W2000934782 hasAuthorship W2000934782A5020168034 @default.
• W2000934782 hasAuthorship W2000934782A5023613168 @default.
• W2000934782 hasAuthorship W2000934782A5031891304 @default.
• W2000934782 hasConcept C126322002 @default.
• W2000934782 hasConcept C134018914 @default.
• W2000934782 hasConcept C181199279 @default.
• W2000934782 hasConcept C185592680 @default.
• W2000934782 hasConcept C24998067 @default.
• W2000934782 hasConcept C2776524530 @default.
• W2000934782 hasConcept C2778815084 @default.
• W2000934782 hasConcept C2780829032 @default.
• W2000934782 hasConcept C2986274086 @default.
• W2000934782 hasConcept C31903555 @default.
• W2000934782 hasConcept C55493867 @default.
• W2000934782 hasConcept C71924100 @default.
• W2000934782 hasConcept C86803240 @default.
• W2000934782 hasConcept C87644729 @default.
• W2000934782 hasConceptScore W2000934782C126322002 @default.
• W2000934782 hasConceptScore W2000934782C134018914 @default.
• W2000934782 hasConceptScore W2000934782C181199279 @default.
• W2000934782 hasConceptScore W2000934782C185592680 @default.
• W2000934782 hasConceptScore W2000934782C24998067 @default.
• W2000934782 hasConceptScore W2000934782C2776524530 @default.
• W2000934782 hasConceptScore W2000934782C2778815084 @default.
• W2000934782 hasConceptScore W2000934782C2780829032 @default.
• W2000934782 hasConceptScore W2000934782C2986274086 @default.
• W2000934782 hasConceptScore W2000934782C31903555 @default.
• W2000934782 hasConceptScore W2000934782C55493867 @default.
• W2000934782 hasConceptScore W2000934782C71924100 @default.
• W2000934782 hasConceptScore W2000934782C86803240 @default.
• W2000934782 hasConceptScore W2000934782C87644729 @default.
• W2000934782 hasIssue "1" @default.
• W2000934782 hasLocation W20009347821 @default.
• W2000934782 hasLocation W20009347822 @default.
• W2000934782 hasOpenAccess W2000934782 @default.
• W2000934782 hasPrimaryLocation W20009347821 @default.
• W2000934782 hasRelatedWork W138479930 @default.
• W2000934782 hasRelatedWork W2028606484 @default.
• W2000934782 hasRelatedWork W2062851024 @default.
• W2000934782 hasRelatedWork W2072083122 @default.
• W2000934782 hasRelatedWork W2079089904 @default.
• W2000934782 hasRelatedWork W2106765926 @default.
• W2000934782 hasRelatedWork W2152342291 @default.
• W2000934782 hasRelatedWork W2401493241 @default.
• W2000934782 hasRelatedWork W2420833660 @default.
• W2000934782 hasRelatedWork W2423675590 @default.
• W2000934782 hasVolume "663" @default.
• W2000934782 isParatext "false" @default.
• W2000934782 isRetracted "false" @default.
• W2000934782 magId "2000934782" @default.
• W2000934782 workType "article" @default.