FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000934900> ?p ?o ?g. }

• W2000934900 endingPage "5611" @default.
• W2000934900 startingPage "5604" @default.
• W2000934900 abstract "ABSTRACT The innate ability of Streptococcus pneumoniae to resist complement activation and complement-mediated phagocytosis may be a direct consequence of the ability of the bacteria to bind components of the complement regulatory system. One such component, factor H (fH), is a crucial fluid-phase negative regulator of the alternative pathway of complement and is utilized by a number of pathogenic organisms to resist complement attack. The pneumococcal surface protein C (PspC [also known as CbpA] and SpsA) has been shown to bind fH, although the exact binding site within one or more of the 20 short consensus repeats (SCRs) of the molecule is not known. The purpose of the current study was to map specific SCRs on fH responsible for this binding. Initial experiments utilizing type 2 pneumococcal strain D39 and its isogenic PspC-negative derivative (D39/ pspC mutant) showed that fH binding was PspC dependent. A purified recombinant protein derivative of PspC that lacked the proline-rich region (PspCΔPro) had a reduced binding efficiency for fH, thereby directly showing the importance of this region for the fH interaction. We have specifically shown by inhibition experiments that SCRs responsible for heparin and C3b binding of fH are not involved in binding PspC and the interaction between fH and PspC is largely hydrophobic, since no inhibition was observed in the presence of high concentrations of NaCl. Construction of SCR proteins encompassing the whole fH molecule showed that SCRs 8 to 15 (SCR 8-15) mediated binding to PspC. Further localization experiments revealed that SCR 13 and SCR 15 were required for full binding, although partial binding was retained when either SCR was removed." @default.
• W2000934900 created "2016-06-24" @default.
• W2000934900 creator A5021760469 @default.
• W2000934900 creator A5024460120 @default.
• W2000934900 creator A5040961140 @default.
• W2000934900 creator A5048357573 @default.
• W2000934900 creator A5054896254 @default.
• W2000934900 creator A5055597053 @default.
• W2000934900 creator A5082223262 @default.
• W2000934900 date "2002-10-01" @default.
• W2000934900 modified "2023-09-26" @default.
• W2000934900 title "The Human Complement Regulator Factor H Binds Pneumococcal Surface Protein PspC via Short Consensus Repeats 13 to 15" @default.
• W2000934900 cites W1492385697 @default.
• W2000934900 cites W1503240365 @default.
• W2000934900 cites W1529745308 @default.
• W2000934900 cites W1569686393 @default.
• W2000934900 cites W1600561684 @default.
• W2000934900 cites W1827417957 @default.
• W2000934900 cites W1910760362 @default.
• W2000934900 cites W1919786812 @default.
• W2000934900 cites W1948307823 @default.
• W2000934900 cites W1964578552 @default.
• W2000934900 cites W1968766773 @default.
• W2000934900 cites W1985498833 @default.
• W2000934900 cites W2005741947 @default.
• W2000934900 cites W2011323677 @default.
• W2000934900 cites W2051206596 @default.
• W2000934900 cites W2051430573 @default.
• W2000934900 cites W2052759282 @default.
• W2000934900 cites W2061501964 @default.
• W2000934900 cites W2068664566 @default.
• W2000934900 cites W2070088956 @default.
• W2000934900 cites W2070783701 @default.
• W2000934900 cites W2071842931 @default.
• W2000934900 cites W2073745575 @default.
• W2000934900 cites W2080583506 @default.
• W2000934900 cites W2090273752 @default.
• W2000934900 cites W2101284109 @default.
• W2000934900 cites W2102387303 @default.
• W2000934900 cites W2103613627 @default.
• W2000934900 cites W2120980915 @default.
• W2000934900 cites W2129847700 @default.
• W2000934900 cites W2139284625 @default.
• W2000934900 cites W2144471192 @default.
• W2000934900 cites W2156732183 @default.
• W2000934900 cites W2161469264 @default.
• W2000934900 cites W2162339585 @default.
• W2000934900 cites W2163188120 @default.
• W2000934900 cites W2170651898 @default.
• W2000934900 doi "https://doi.org/10.1128/iai.70.10.5604-5611.2002" @default.
• W2000934900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/128338" @default.
• W2000934900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12228288" @default.
• W2000934900 hasPublicationYear "2002" @default.
• W2000934900 type Work @default.
• W2000934900 sameAs 2000934900 @default.
• W2000934900 citedByCount "85" @default.
• W2000934900 countsByYear W20009349002012 @default.
• W2000934900 countsByYear W20009349002013 @default.
• W2000934900 countsByYear W20009349002014 @default.
• W2000934900 countsByYear W20009349002015 @default.
• W2000934900 countsByYear W20009349002016 @default.
• W2000934900 countsByYear W20009349002018 @default.
• W2000934900 countsByYear W20009349002019 @default.
• W2000934900 countsByYear W20009349002020 @default.
• W2000934900 countsByYear W20009349002021 @default.
• W2000934900 countsByYear W20009349002022 @default.
• W2000934900 crossrefType "journal-article" @default.
• W2000934900 hasAuthorship W2000934900A5021760469 @default.
• W2000934900 hasAuthorship W2000934900A5024460120 @default.
• W2000934900 hasAuthorship W2000934900A5040961140 @default.
• W2000934900 hasAuthorship W2000934900A5048357573 @default.
• W2000934900 hasAuthorship W2000934900A5054896254 @default.
• W2000934900 hasAuthorship W2000934900A5055597053 @default.
• W2000934900 hasAuthorship W2000934900A5082223262 @default.
• W2000934900 hasBestOaLocation W20009349002 @default.
• W2000934900 hasConcept C104317684 @default.
• W2000934900 hasConcept C107824862 @default.
• W2000934900 hasConcept C111684460 @default.
• W2000934900 hasConcept C138873322 @default.
• W2000934900 hasConcept C143065580 @default.
• W2000934900 hasConcept C14356644 @default.
• W2000934900 hasConcept C153911025 @default.
• W2000934900 hasConcept C159654299 @default.
• W2000934900 hasConcept C171279029 @default.
• W2000934900 hasConcept C189446657 @default.
• W2000934900 hasConcept C2776809874 @default.
• W2000934900 hasConcept C2781253189 @default.
• W2000934900 hasConcept C40767141 @default.
• W2000934900 hasConcept C523546767 @default.
• W2000934900 hasConcept C54355233 @default.
• W2000934900 hasConcept C55493867 @default.
• W2000934900 hasConcept C86803240 @default.
• W2000934900 hasConcept C89423630 @default.
• W2000934900 hasConceptScore W2000934900C104317684 @default.
• W2000934900 hasConceptScore W2000934900C107824862 @default.
• W2000934900 hasConceptScore W2000934900C111684460 @default.
• W2000934900 hasConceptScore W2000934900C138873322 @default.
• W2000934900 hasConceptScore W2000934900C143065580 @default.

• next