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- W2000935248 abstract "2-Aminonicotinaldehyde 1 on condensation with p-chlorophenylacetonitrile 2 affords 2-amino-3-(p-chlorophenyl)-1,8-naphthyridine 3, which is converted into 2-hydrazino-3-(p-chlorophenyl)-1,8-naphthyridinc 4 by the reactionwith hydrazine hydrate and cone. HCl. The hydrazino compound 4 undergo condensation with aromatic aldehydes to give the corresponding 3-(p-chlorophenyl)-1,8-naphthyridin-2-ylhydrazones 5, which on oxidation with iodobenzene diacetate (IBD) in dichloromethane at room temperature furnishes 1-aryl-4-(p-chlorophenyl)-1,2,4-triazolo[4,3-a][1,8]naphthyridines 6. Structural assignments of the products are based on their elemental analyses and spectral (IR, 1 H NMR and MS) data. Compounds 6 synthesized have been screened for their antibacterial activity." @default.
- W2000935248 created "2016-06-24" @default.
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- W2000935248 date "2003-01-07" @default.
- W2000935248 modified "2023-10-14" @default.
- W2000935248 title "Hypervalent Iodine Mediated Synthesis of 1,2,4-Triazolo[4,3-a][1,8]naphthyridines." @default.
- W2000935248 cites W2951672864 @default.
- W2000935248 doi "https://doi.org/10.1002/chin.200301145" @default.
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