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• W2000935483 abstract "Vitamin D insufficiency is very common and is known to cause secondary hyperparathyroidism (SHPT). However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT).We compared indices of calcium homeostasis, bone metabolism and body composition in subjects with differential PTH responses to low vitamin D levels.Cross-sectional study. In 405 recent postmenopausal women with vitamin D insufficiency, we compared levels of bone turnover markers, bone mineral density (BMD), body composition, and body weight between subjects with SHPT and FHPT.Plasma 25-hydroxyvitamin D (P-25OHD) levels were slightly higher (P < 0.05) in SHPT compared with FHPT. SHPT was associated with higher levels of osteocalcin and bone-specific alkaline phosphatase, whereas whole body BMD and hip- and lumbar spine-BMD were significantly reduced. Subjects with SHPT had a 7% (P < 0.01) higher body weight and a 23% higher fat mass (P < 0.01) than subjects with FHPT, whereas lean tissue mass did not differ between groups. In SHPT, fat mass was increased by 14% (P < 0.001) at the upper and lower extremities and by 33% (P < 0.001) at the trunk. In a regression model, significant predictors of fat mass was P-PTH (r(p) = 0.248, P < 0.01) and P-osteocalcin (r(p) = -0.115, P = 0.02), with no effects of P-25OHD or P-creatinine levels.Effects of vitamin D insufficiency on bone is associated with the PTH responses. The increased body weight and fat mass in SHPT compared with FHPT may imply that PTH excess contributes to fat accumulation." @default.
• W2000935483 created "2016-06-24" @default.
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• W2000935483 date "2008-06-28" @default.
• W2000935483 modified "2023-10-15" @default.
• W2000935483 title "Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics" @default.
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• W2000935483 doi "https://doi.org/10.1111/j.1365-2265.2008.03186.x" @default.
• W2000935483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18208576" @default.
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