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- W2000936413 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILRecently, we have designed and synthesized a novel quinoxalinhydrazide, SC144, that showed cytotoxicity in a panel of human cancer cell lines. Here, we found that SC144 exhibited anticancer activity in a panel of drug-sensitive and drug-resistant colon cancer cell lines. To study the molecular anticancer mechanism of SC144, we further found that it arrested cell cycle progression and induced apoptosis in colon cancer cells, which is associated with the decrease in cyclin D1 expression and the activation of the p38/IL-24/Fas pathway. Additionally, in surgical specimens from 202 colorectal patients, Cyclin D1 expression was significantly higher and IL-24 expression was significantly lower in cancer tissue than in adjacent normal mucosa, and there was a significant correlation between IL-24 level in colorectal cancer tissue and the survival rate of patients after cytoreductive surgery (P = 0.007). This clinical evidence further supports that SC144 is a promising therapeutic agent for colon cancer therapy.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1927. doi:1538-7445.AM2012-1927" @default.
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- W2000936413 date "2012-04-15" @default.
- W2000936413 modified "2023-09-25" @default.
- W2000936413 title "Abstract 1927: Mechanistic characterization of SC144 in colon cancer" @default.
- W2000936413 doi "https://doi.org/10.1158/1538-7445.am2012-1927" @default.
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