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• W2000937419 startingPage "5696" @default.
• W2000937419 abstract "ABSTRACT The human cytomegalovirus (HCMV) ORF94 gene product has been reported to be expressed during both productive and latent phases of infection, although its function is unknown. We report that expression of pORF94 leads to decreased 2′,5′-oligoadenylate synthetase (OAS) expression in transfected cells with and without interferon stimulation. Furthermore, the functional activity of OAS was inhibited by pORF94. Finally, we present evidence of OAS modulation by pORF94 during productive HCMV infection of human fibroblasts. This study provides the first identification of a function for pORF94 and identifies an additional means by which HCMV may limit a critical host cell antiviral response." @default.
• W2000937419 created "2016-06-24" @default.
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• W2000937419 date "2011-06-01" @default.
• W2000937419 modified "2023-10-03" @default.
• W2000937419 title "Inhibition of 2′,5′-Oligoadenylate Synthetase Expression and Function by the Human Cytomegalovirus ORF94 Gene Product" @default.
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• W2000937419 doi "https://doi.org/10.1128/jvi.02463-10" @default.
• W2000937419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3094971" @default.
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• W2000937419 hasPublicationYear "2011" @default.
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