Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000937701> ?p ?o ?g. }
- W2000937701 endingPage "344" @default.
- W2000937701 startingPage "333" @default.
- W2000937701 abstract "Growing attention has been given to the potential of pulmonary route as an alternative for non-invasive systemic delivery of therapeutic agents. In this study, novel nebulizer-compatible solid lipid nanoparticles (SLNs) for pulmonary drug delivery of insulin were developed by reverse micelle-double emulsion method. The influences of the amount of sodium cholate (SC) and soybean phosphatidylcholine (SPC) on the deposition properties of the nanoparticles were investigated. Under optimal conditions, the entrapment delivery (ED), respirable fraction (RF) and nebulization efficiency (NE) of SLNs could reach 96.53, 82.11 and 63.28%, respectively, and Ins–SLNs remained stable during nebulization. Fasting plasma glucose level was reduced to 39.41% and insulin level was increased to approximately 170 μIU/ml 4 h after pulmonary administration of 20 IU/kg Ins–SLNs. A pharmacological bioavailability of 24.33% and a relative bioavailability of 22.33% were obtained using subcutaneous injection as a reference. Incorporating fluorescent-labelled insulin into SLNs, we found that the SLNs were effectively and homogeneously distributed in the lung alveoli. These findings suggested that SLNs could be used as a potential carrier for pulmonary delivery of insulin by improving both in vitro and in vivo stability as well as prolonging hypoglycemic effect, which inevitably resulted in enhanced bioavailability." @default.
- W2000937701 created "2016-06-24" @default.
- W2000937701 creator A5001421484 @default.
- W2000937701 creator A5003372705 @default.
- W2000937701 creator A5026174200 @default.
- W2000937701 creator A5035994337 @default.
- W2000937701 creator A5063127492 @default.
- W2000937701 creator A5068290128 @default.
- W2000937701 creator A5071768432 @default.
- W2000937701 creator A5075158998 @default.
- W2000937701 creator A5086373985 @default.
- W2000937701 date "2008-05-01" @default.
- W2000937701 modified "2023-10-17" @default.
- W2000937701 title "Solid lipid nanoparticles for pulmonary delivery of insulin" @default.
- W2000937701 cites W113791819 @default.
- W2000937701 cites W1511437561 @default.
- W2000937701 cites W152528252 @default.
- W2000937701 cites W1558228970 @default.
- W2000937701 cites W1565091296 @default.
- W2000937701 cites W1964378871 @default.
- W2000937701 cites W1970366395 @default.
- W2000937701 cites W1973204178 @default.
- W2000937701 cites W1974166640 @default.
- W2000937701 cites W1976233456 @default.
- W2000937701 cites W1978357008 @default.
- W2000937701 cites W1979018924 @default.
- W2000937701 cites W1985119102 @default.
- W2000937701 cites W1985343231 @default.
- W2000937701 cites W1993362223 @default.
- W2000937701 cites W1999122040 @default.
- W2000937701 cites W1999375292 @default.
- W2000937701 cites W1999467041 @default.
- W2000937701 cites W2003423403 @default.
- W2000937701 cites W2003438389 @default.
- W2000937701 cites W2003629077 @default.
- W2000937701 cites W2015285361 @default.
- W2000937701 cites W2016692322 @default.
- W2000937701 cites W2020689393 @default.
- W2000937701 cites W2023456252 @default.
- W2000937701 cites W2025373577 @default.
- W2000937701 cites W2038553101 @default.
- W2000937701 cites W2039057262 @default.
- W2000937701 cites W2042027036 @default.
- W2000937701 cites W2042612658 @default.
- W2000937701 cites W2043105290 @default.
- W2000937701 cites W2044114249 @default.
- W2000937701 cites W2044399330 @default.
- W2000937701 cites W2048194104 @default.
- W2000937701 cites W2049342338 @default.
- W2000937701 cites W2057008152 @default.
- W2000937701 cites W2065254628 @default.
- W2000937701 cites W2068601883 @default.
- W2000937701 cites W2069233565 @default.
- W2000937701 cites W2070823215 @default.
- W2000937701 cites W2077284777 @default.
- W2000937701 cites W2077317248 @default.
- W2000937701 cites W2100139706 @default.
- W2000937701 cites W2115533786 @default.
- W2000937701 cites W2124596793 @default.
- W2000937701 cites W2128104724 @default.
- W2000937701 cites W2137397041 @default.
- W2000937701 cites W2144678672 @default.
- W2000937701 cites W2152782396 @default.
- W2000937701 cites W2153962345 @default.
- W2000937701 cites W2156874182 @default.
- W2000937701 cites W2161034880 @default.
- W2000937701 cites W2170060628 @default.
- W2000937701 cites W301992919 @default.
- W2000937701 cites W3199261357 @default.
- W2000937701 cites W4234498964 @default.
- W2000937701 cites W59258389 @default.
- W2000937701 doi "https://doi.org/10.1016/j.ijpharm.2008.01.008" @default.
- W2000937701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18281169" @default.
- W2000937701 hasPublicationYear "2008" @default.
- W2000937701 type Work @default.
- W2000937701 sameAs 2000937701 @default.
- W2000937701 citedByCount "207" @default.
- W2000937701 countsByYear W20009377012012 @default.
- W2000937701 countsByYear W20009377012013 @default.
- W2000937701 countsByYear W20009377012014 @default.
- W2000937701 countsByYear W20009377012015 @default.
- W2000937701 countsByYear W20009377012016 @default.
- W2000937701 countsByYear W20009377012017 @default.
- W2000937701 countsByYear W20009377012018 @default.
- W2000937701 countsByYear W20009377012019 @default.
- W2000937701 countsByYear W20009377012020 @default.
- W2000937701 countsByYear W20009377012021 @default.
- W2000937701 countsByYear W20009377012022 @default.
- W2000937701 countsByYear W20009377012023 @default.
- W2000937701 crossrefType "journal-article" @default.
- W2000937701 hasAuthorship W2000937701A5001421484 @default.
- W2000937701 hasAuthorship W2000937701A5003372705 @default.
- W2000937701 hasAuthorship W2000937701A5026174200 @default.
- W2000937701 hasAuthorship W2000937701A5035994337 @default.
- W2000937701 hasAuthorship W2000937701A5063127492 @default.
- W2000937701 hasAuthorship W2000937701A5068290128 @default.
- W2000937701 hasAuthorship W2000937701A5071768432 @default.
- W2000937701 hasAuthorship W2000937701A5075158998 @default.