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- W2000937910 abstract "Interleukin-8 (IL-8) is the predominant cytokine expressed in the female genital tract of women with certain infectious/inflammatory conditions. IL-8 increased HIV-1 replication in T cells and to a greater extent in monocytes/macrophages in vitro. Physiological levels of IL-8 increased susceptibility to HIV-1 infection 5- to 8-fold in cervical explant tissues. Competitive inhibition of the IL-8 receptor CXCR2 with the small molecule inhibitor SB225002 resulted in a 45–70% decrease in cervical explant susceptibility to HIV-1 infection." @default.
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- W2000937910 date "2005-03-01" @default.
- W2000937910 modified "2023-10-17" @default.
- W2000937910 title "IL-8 Increases Transmission of HIV Type 1 in Cervical Explant Tissue" @default.
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- W2000937910 doi "https://doi.org/10.1089/aid.2005.21.228" @default.
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