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- W2000939006 endingPage "1951" @default.
- W2000939006 startingPage "1948" @default.
- W2000939006 abstract "Sodium salts of four of the most active antineoplastic agents in a series of α-(N)-heterocyclic carboxaldehyde thiosemicarbazones have been prepared as a means of solubilizing for parenteral administration these extremely insoluble compounds. The sodium salt of 1-formylisoquinoline thiosemicarbazone (II) is soluble in non-aqueous vehicles for injection such as propylene glycol, whereas the sodium salts of 5-hydroxy-1-formylisoquinoline thiosemicarbazone (III), 3-hydroxy-2-formylpyridine thiosemicarbazone (IV), and 5-hydroxy-2-formylpyridine thiosemicarbazone (V) are readily soluble in water. Compounds III and IV, at the optimum effective dosage regimens, caused a greater prolongation of the survival time of mice bearing the L1210 lymphoma than did the parent derivatives, while II and V produced antineoplastic activity against sarcoma 180 and the L1210 lymphoma, respectively, equivalent to that of the parent compounds." @default.
- W2000939006 created "2016-06-24" @default.
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- W2000939006 date "1968-11-01" @default.
- W2000939006 modified "2023-09-23" @default.
- W2000939006 title "Potential Antitumor Agents III" @default.
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- W2000939006 doi "https://doi.org/10.1002/jps.2600571125" @default.
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