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- W2000939065 abstract "Chronic neuropathic pain is a frequent comorbidity following spinal cord injury (SCI) and often fails to respond to conventional pain management strategies. Preventive administration of docosahexaenoic acid (DHA) or the consumption of a diet rich in omega-3 polyunsaturated fatty acids (O3PUFAs) confers potent prophylaxis against SCI and improves functional recovery. The present study examines whether this novel dietary strategy provides significant antinociceptive benefits in rats experiencing SCI-induced pain. Rats were fed control chow or chow enriched with O3PUFAs for 8 weeks before being subjected to sham or cord contusion surgeries, continuing the same diets after surgery for another 8 more weeks. The paw sensitivity to noxious heat was quantified for at least 8 weeks post-SCI using the Hargreaves test. We found that SCI rats consuming the preventive O3PUFA-enriched diet exhibited a significant reduction in thermal hyperalgesia compared to those consuming the normal diet. Functional neurometabolomic profiling revealed a distinctive deregulation in the metabolism of endocannabinoids (eCB) and related N-acyl ethanolamines (NAEs) at 8 weeks post-SCI. We found that O3PUFAs consumption led to a robust accumulation of novel NAE precursors, including the glycerophospho-containing docosahexaenoyl ethanolamine (DHEA), docosapentaenoyl ethanolamine (DPEA), and eicosapentaenoyl ethanolamine (EPEA). The tissue levels of these metabolites were significantly correlated with the antihyperalgesic phenotype. In addition, rats consuming the O3PUFA-rich diet showed reduced sprouting of nociceptive fibers containing CGRP and dorsal horn neuron p38 mitogen-activated protein kinase (MAPK) expression, well-established biomarkers of pain. The spinal cord levels of inositols were positively correlated with thermal hyperalgesia, supporting their role as biomarkers of chronic neuropathic pain. Notably, the O3PUFA-rich dietary intervention reduced the levels of these metabolites. Collectively, these results demonstrate the prophylactic value of dietary O3PUFA against SCI-mediated chronic pain." @default.
- W2000939065 created "2016-06-24" @default.
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- W2000939065 creator A5080141967 @default.
- W2000939065 date "2013-12-01" @default.
- W2000939065 modified "2023-10-17" @default.
- W2000939065 title "Metabolomics uncovers dietary omega-3 fatty acid-derived metabolites implicated in anti-nociceptive responses after experimental spinal cord injury" @default.
- W2000939065 cites W1547958427 @default.
- W2000939065 cites W1555078357 @default.
- W2000939065 cites W1578820780 @default.
- W2000939065 cites W1615976536 @default.
- W2000939065 cites W1829029306 @default.
- W2000939065 cites W1964526782 @default.
- W2000939065 cites W1964895626 @default.
- W2000939065 cites W1965704091 @default.
- W2000939065 cites W1966547087 @default.
- W2000939065 cites W1967162890 @default.
- W2000939065 cites W1972822926 @default.
- W2000939065 cites W1973273107 @default.
- W2000939065 cites W1975161769 @default.
- W2000939065 cites W1975724680 @default.
- W2000939065 cites W1976581481 @default.
- W2000939065 cites W1982185581 @default.
- W2000939065 cites W1984413479 @default.
- W2000939065 cites W1984769120 @default.
- W2000939065 cites W1988889477 @default.
- W2000939065 cites W1989073099 @default.
- W2000939065 cites W1989454487 @default.
- W2000939065 cites W1992530514 @default.
- W2000939065 cites W1995275029 @default.
- W2000939065 cites W1995648211 @default.
- W2000939065 cites W1995824684 @default.
- W2000939065 cites W1999275970 @default.
- W2000939065 cites W2000822411 @default.
- W2000939065 cites W2001159571 @default.
- W2000939065 cites W2003954385 @default.
- W2000939065 cites W2006944304 @default.
- W2000939065 cites W2006962536 @default.
- W2000939065 cites W2010376916 @default.
- W2000939065 cites W2010474996 @default.
- W2000939065 cites W2012024320 @default.
- W2000939065 cites W2012924135 @default.
- W2000939065 cites W2014007136 @default.
- W2000939065 cites W2014596724 @default.
- W2000939065 cites W2014598762 @default.
- W2000939065 cites W2014614933 @default.
- W2000939065 cites W2016078643 @default.
- W2000939065 cites W2016542037 @default.
- W2000939065 cites W2019207254 @default.
- W2000939065 cites W2021132159 @default.
- W2000939065 cites W2023167145 @default.
- W2000939065 cites W2023798788 @default.
- W2000939065 cites W2024782047 @default.
- W2000939065 cites W2030237842 @default.
- W2000939065 cites W2032524903 @default.
- W2000939065 cites W2032798997 @default.
- W2000939065 cites W2036878027 @default.
- W2000939065 cites W2037564048 @default.
- W2000939065 cites W2039066274 @default.
- W2000939065 cites W2040871722 @default.
- W2000939065 cites W2050324752 @default.
- W2000939065 cites W2050667858 @default.
- W2000939065 cites W2053037897 @default.
- W2000939065 cites W2053414031 @default.
- W2000939065 cites W2056071356 @default.
- W2000939065 cites W2057054987 @default.
- W2000939065 cites W2058814496 @default.
- W2000939065 cites W2060669486 @default.
- W2000939065 cites W2061301719 @default.
- W2000939065 cites W2063848910 @default.
- W2000939065 cites W2065677647 @default.
- W2000939065 cites W2065885587 @default.
- W2000939065 cites W2067349578 @default.
- W2000939065 cites W2067637071 @default.
- W2000939065 cites W2071222789 @default.
- W2000939065 cites W2074128028 @default.
- W2000939065 cites W2074806151 @default.
- W2000939065 cites W2076973182 @default.
- W2000939065 cites W2077483410 @default.
- W2000939065 cites W2080185837 @default.
- W2000939065 cites W2081810711 @default.
- W2000939065 cites W2083512888 @default.
- W2000939065 cites W2084154023 @default.
- W2000939065 cites W2084249153 @default.
- W2000939065 cites W2098781914 @default.
- W2000939065 cites W2102092224 @default.
- W2000939065 cites W2103752548 @default.
- W2000939065 cites W2111775116 @default.
- W2000939065 cites W2120365267 @default.
- W2000939065 cites W2120990276 @default.
- W2000939065 cites W2127455024 @default.
- W2000939065 cites W2133740866 @default.
- W2000939065 cites W2135265438 @default.