Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000939717> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2000939717 endingPage "928" @default.
- W2000939717 startingPage "922" @default.
- W2000939717 abstract "In neonatal rat islet cells prelabelled with [14C-methyl] choline, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate rapidly activated a phospholipase D-like mechanism as suggested by the accumulation in cells and medium of choline (but not of phosphorylcholine or glycerophosphorylcholine, markers for phospholipase C and phospholipase A2 action on phosphatidylcholine). This finding was confirmed by a rise in phosphatidic acid (but not diglyceride or arachidonic acid) in fatty acid-labelled cells. Phospholipase D was also activated by ionomycin or sodium fluoride; however, this was accompanied by parallel increases in diglyceride, monoacylglycerol and arachidonic acid in the absence of phosphorylcholine generation, suggesting that these agents also activated a phospholipase C-diglyceride lipase pathway acting on non-choline-containing phosphoglycerides (presumably phosphoinositides). In conjunction with our recent demonstration of insulinotropic effects of phosphatidic acid (M. Dunlop and R. Larkins,Diabetes, in press), our findings suggest for the first time a possible role for phospholipase D activation in the stimulation of insulin release and may imply a novel site of action for phorbol esters in the regulation of exocytosis." @default.
- W2000939717 created "2016-06-24" @default.
- W2000939717 creator A5081249786 @default.
- W2000939717 creator A5089866905 @default.
- W2000939717 date "1989-09-01" @default.
- W2000939717 modified "2023-09-26" @default.
- W2000939717 title "A phospholipase D-like mechanism in pancreatic islet cells: Stimulation by calcium ionophore, phorbol ester and sodium fluoride" @default.
- W2000939717 cites W1493283928 @default.
- W2000939717 cites W1514141833 @default.
- W2000939717 cites W1549576466 @default.
- W2000939717 cites W1574428487 @default.
- W2000939717 cites W1969807210 @default.
- W2000939717 cites W1970398807 @default.
- W2000939717 cites W2010782867 @default.
- W2000939717 cites W2411503300 @default.
- W2000939717 doi "https://doi.org/10.1016/0006-291x(89)92310-3" @default.
- W2000939717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2675833" @default.
- W2000939717 hasPublicationYear "1989" @default.
- W2000939717 type Work @default.
- W2000939717 sameAs 2000939717 @default.
- W2000939717 citedByCount "34" @default.
- W2000939717 crossrefType "journal-article" @default.
- W2000939717 hasAuthorship W2000939717A5081249786 @default.
- W2000939717 hasAuthorship W2000939717A5089866905 @default.
- W2000939717 hasConcept C12927208 @default.
- W2000939717 hasConcept C181199279 @default.
- W2000939717 hasConcept C185592680 @default.
- W2000939717 hasConcept C195794163 @default.
- W2000939717 hasConcept C2776387844 @default.
- W2000939717 hasConcept C2776551241 @default.
- W2000939717 hasConcept C2776909261 @default.
- W2000939717 hasConcept C2776989580 @default.
- W2000939717 hasConcept C2778078955 @default.
- W2000939717 hasConcept C2778597717 @default.
- W2000939717 hasConcept C2778918659 @default.
- W2000939717 hasConcept C2780902120 @default.
- W2000939717 hasConcept C36020004 @default.
- W2000939717 hasConcept C41625074 @default.
- W2000939717 hasConcept C543025807 @default.
- W2000939717 hasConcept C55493867 @default.
- W2000939717 hasConcept C62478195 @default.
- W2000939717 hasConcept C79879829 @default.
- W2000939717 hasConceptScore W2000939717C12927208 @default.
- W2000939717 hasConceptScore W2000939717C181199279 @default.
- W2000939717 hasConceptScore W2000939717C185592680 @default.
- W2000939717 hasConceptScore W2000939717C195794163 @default.
- W2000939717 hasConceptScore W2000939717C2776387844 @default.
- W2000939717 hasConceptScore W2000939717C2776551241 @default.
- W2000939717 hasConceptScore W2000939717C2776909261 @default.
- W2000939717 hasConceptScore W2000939717C2776989580 @default.
- W2000939717 hasConceptScore W2000939717C2778078955 @default.
- W2000939717 hasConceptScore W2000939717C2778597717 @default.
- W2000939717 hasConceptScore W2000939717C2778918659 @default.
- W2000939717 hasConceptScore W2000939717C2780902120 @default.
- W2000939717 hasConceptScore W2000939717C36020004 @default.
- W2000939717 hasConceptScore W2000939717C41625074 @default.
- W2000939717 hasConceptScore W2000939717C543025807 @default.
- W2000939717 hasConceptScore W2000939717C55493867 @default.
- W2000939717 hasConceptScore W2000939717C62478195 @default.
- W2000939717 hasConceptScore W2000939717C79879829 @default.
- W2000939717 hasIssue "2" @default.
- W2000939717 hasLocation W20009397171 @default.
- W2000939717 hasLocation W20009397172 @default.
- W2000939717 hasOpenAccess W2000939717 @default.
- W2000939717 hasPrimaryLocation W20009397171 @default.
- W2000939717 hasRelatedWork W1919686919 @default.
- W2000939717 hasRelatedWork W2000939717 @default.
- W2000939717 hasRelatedWork W2029142943 @default.
- W2000939717 hasRelatedWork W2062200984 @default.
- W2000939717 hasRelatedWork W2062637617 @default.
- W2000939717 hasRelatedWork W2080846485 @default.
- W2000939717 hasRelatedWork W2338880110 @default.
- W2000939717 hasRelatedWork W2397789650 @default.
- W2000939717 hasRelatedWork W4231141719 @default.
- W2000939717 hasRelatedWork W42987530 @default.
- W2000939717 hasVolume "163" @default.
- W2000939717 isParatext "false" @default.
- W2000939717 isRetracted "false" @default.
- W2000939717 magId "2000939717" @default.
- W2000939717 workType "article" @default.