Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000939949> ?p ?o ?g. }
- W2000939949 endingPage "280" @default.
- W2000939949 startingPage "269" @default.
- W2000939949 abstract "Caprine arthritis encephalitis virus (CAEV) is the natural lentivirus of goats, well known for its tropism for macrophages and its inability to cause infection in lymphocytes. The viral genome lacks nef, tat, vpu and vpx coding sequences. To test the hypothesis that when nef is expressed by the viral genome, the virus became toxic for lymphocytes during replication in macrophages, we inserted the SIVsmm PBj14 nef coding sequences into the genome of CAEV thereby generating CAEV-nef. This recombinant virus is not infectious for lymphocytes but is fully replication competent in goat macrophages in which it constitutively expresses the SIV Nef. We found that goat lymphocytes cocultured with CAEV-nef-infected macrophages became activated, showing increased expression of the interleukin-2 receptor (IL-2R). Activation correlated with increased proliferation of the cells. Interestingly, a dual effect in terms of apoptosis regulation was observed in exposed goat lymphocytes. Nef was found first to induce a protection of lymphocytes from apoptosis during the first few days following exposure to infected macrophages, but later it induced increased apoptosis in the activated lymphocytes. This new recombinant virus provides a model to study the functions of Nef in the context of infection of macrophages, but in absence of infection of T lymphocytes and brings new insights into the biological effects of Nef on lymphocytes." @default.
- W2000939949 created "2016-06-24" @default.
- W2000939949 creator A5001619169 @default.
- W2000939949 creator A5006526104 @default.
- W2000939949 creator A5014145005 @default.
- W2000939949 creator A5023542165 @default.
- W2000939949 creator A5026349233 @default.
- W2000939949 creator A5043463019 @default.
- W2000939949 creator A5060546234 @default.
- W2000939949 creator A5066805246 @default.
- W2000939949 date "2007-08-01" @default.
- W2000939949 modified "2023-10-18" @default.
- W2000939949 title "Activation/proliferation and apoptosis of bystander goat lymphocytes induced by a macrophage-tropic chimeric caprine arthritis encephalitis virus expressing SIV Nef" @default.
- W2000939949 cites W1411485922 @default.
- W2000939949 cites W1549697397 @default.
- W2000939949 cites W1576582350 @default.
- W2000939949 cites W1581934447 @default.
- W2000939949 cites W1582864225 @default.
- W2000939949 cites W1644579564 @default.
- W2000939949 cites W167846769 @default.
- W2000939949 cites W1896824500 @default.
- W2000939949 cites W1950343951 @default.
- W2000939949 cites W1966586657 @default.
- W2000939949 cites W1970627375 @default.
- W2000939949 cites W1971356923 @default.
- W2000939949 cites W1976298092 @default.
- W2000939949 cites W1977725360 @default.
- W2000939949 cites W1980962192 @default.
- W2000939949 cites W1983885062 @default.
- W2000939949 cites W1986951584 @default.
- W2000939949 cites W1988677604 @default.
- W2000939949 cites W1990041801 @default.
- W2000939949 cites W1990347667 @default.
- W2000939949 cites W1992139346 @default.
- W2000939949 cites W2002056641 @default.
- W2000939949 cites W2002432452 @default.
- W2000939949 cites W2014074003 @default.
- W2000939949 cites W2017605155 @default.
- W2000939949 cites W2023991533 @default.
- W2000939949 cites W2027772130 @default.
- W2000939949 cites W2029492041 @default.
- W2000939949 cites W2034900005 @default.
- W2000939949 cites W2035091743 @default.
- W2000939949 cites W2042698454 @default.
- W2000939949 cites W2046963695 @default.
- W2000939949 cites W2049805694 @default.
- W2000939949 cites W2051455874 @default.
- W2000939949 cites W2052410900 @default.
- W2000939949 cites W2054395379 @default.
- W2000939949 cites W2063828696 @default.
- W2000939949 cites W2064501033 @default.
- W2000939949 cites W2064557078 @default.
- W2000939949 cites W2070958070 @default.
- W2000939949 cites W2096570932 @default.
- W2000939949 cites W2101181558 @default.
- W2000939949 cites W2106235650 @default.
- W2000939949 cites W2106440871 @default.
- W2000939949 cites W2111256796 @default.
- W2000939949 cites W2111666869 @default.
- W2000939949 cites W2122310985 @default.
- W2000939949 cites W2128064320 @default.
- W2000939949 cites W2128717715 @default.
- W2000939949 cites W2134034689 @default.
- W2000939949 cites W2137817844 @default.
- W2000939949 cites W2138752330 @default.
- W2000939949 cites W2149195560 @default.
- W2000939949 cites W2149676565 @default.
- W2000939949 cites W2149951876 @default.
- W2000939949 cites W2149972150 @default.
- W2000939949 cites W2157230655 @default.
- W2000939949 cites W2159275546 @default.
- W2000939949 cites W2167147506 @default.
- W2000939949 cites W2169588536 @default.
- W2000939949 cites W2169809805 @default.
- W2000939949 cites W2171065789 @default.
- W2000939949 cites W2173863570 @default.
- W2000939949 cites W2283006953 @default.
- W2000939949 cites W2468367304 @default.
- W2000939949 cites W4234715488 @default.
- W2000939949 cites W4246561034 @default.
- W2000939949 cites W4249614921 @default.
- W2000939949 cites W87675469 @default.
- W2000939949 doi "https://doi.org/10.1016/j.virol.2007.02.032" @default.
- W2000939949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2479789" @default.
- W2000939949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17442361" @default.
- W2000939949 hasPublicationYear "2007" @default.
- W2000939949 type Work @default.
- W2000939949 sameAs 2000939949 @default.
- W2000939949 citedByCount "10" @default.
- W2000939949 countsByYear W20009399492016 @default.
- W2000939949 countsByYear W20009399492022 @default.
- W2000939949 countsByYear W20009399492023 @default.
- W2000939949 crossrefType "journal-article" @default.
- W2000939949 hasAuthorship W2000939949A5001619169 @default.
- W2000939949 hasAuthorship W2000939949A5006526104 @default.
- W2000939949 hasAuthorship W2000939949A5014145005 @default.
- W2000939949 hasAuthorship W2000939949A5023542165 @default.
- W2000939949 hasAuthorship W2000939949A5026349233 @default.