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- W2000940697 abstract "Peptide generation by the UPS (ubiquitin–proteasome system) is rate-limiting in MHC class I-restricted antigen presentation in response to virus-induced IFNs (interferons). In this process, the role of IFN-induced rapid remodelling of the UPS is less defined. IFN-mediated de novo formation of different proteasome compositions as i20S (immunoproteasomes) or m20S (mixed-type proteasomes) essentially supports the rapid adjustment of the mammalian immune system to pathogens. This adjustment is of particular importance for the immune response to rapidly replicating viruses. In agreement, i20S formation has been shown to be an accelerated and transient response. Moreover, i20S and/or PA28 (proteasome activator 28) are essentially required for the generation of certain viral epitopes. In the present paper, we discuss how IFNs consecutively regulate the UPS at different levels, thereby improving the immune responsiveness of target cells." @default.
- W2000940697 created "2016-06-24" @default.
- W2000940697 creator A5051217060 @default.
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- W2000940697 date "2008-09-19" @default.
- W2000940697 modified "2023-10-03" @default.
- W2000940697 title "Remodelling of the ubiquitin–proteasome system in response to interferons" @default.
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- W2000940697 doi "https://doi.org/10.1042/bst0360879" @default.
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