FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000941383> ?p ?o ?g. }

• W2000941383 endingPage "1634" @default.
• W2000941383 startingPage "1618" @default.
• W2000941383 abstract "The interaction of nominal Ag with major histocompatibility complex (MHC)-restricted T cells and accessory cells was studied by analyzing the effect of structurally related antigens on the response of antigen-specific MHC-restricted T cell hybridomas. The copolymer L-glutamic acid50-L-tyrosine50 (GT) completely inhibits the response of L-glutamic acid60-L-alanine40-L-tyrosine10 (GAT)-specific, I-Ad-restricted T cell hybridomas to GAT plus accessory cells. This inhibition is specific, as hybridomas of other specificities are not inhibited under identical conditions, and is unique to the GT antigen, as other similar copolymers are not inhibitory. The inhibitory effect is reversible by adding increasing amounts of GAT. Antigen-pulsing experiments localized the inhibition to the level of antigen-presenting cell (APC). GT-prepulsed APC are not inhibitory in cell-mixing experiments and can present other antigens. GT only inhibits the nominal antigen-directed component of a GAT-specific, autoreactive hybrid's response. Together these findings suggest that GT causes inhibition by competing for GAT association at the accessory cell. GT interferes with GAT presentation by an I-Adxb F1 APC to a BALB/c, I-Ad-restricted, but not B10, I-Ab-restricted, T cell hybridoma, and GT inhibits presentation by GAT-prepulsed APC. The implications of these findings for MHC-restricted presentation of antigen are discussed." @default.
• W2000941383 created "2016-06-24" @default.
• W2000941383 creator A5001497872 @default.
• W2000941383 creator A5082096834 @default.
• W2000941383 date "1983-05-01" @default.
• W2000941383 modified "2023-09-30" @default.
• W2000941383 title "Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation." @default.
• W2000941383 cites W1493816460 @default.
• W2000941383 cites W1498621464 @default.
• W2000941383 cites W1506157243 @default.
• W2000941383 cites W1521286109 @default.
• W2000941383 cites W1530422829 @default.
• W2000941383 cites W1564309137 @default.
• W2000941383 cites W1564830378 @default.
• W2000941383 cites W1589480977 @default.
• W2000941383 cites W1602167378 @default.
• W2000941383 cites W1603914738 @default.
• W2000941383 cites W1747394534 @default.
• W2000941383 cites W1813912614 @default.
• W2000941383 cites W1943330801 @default.
• W2000941383 cites W1968715585 @default.
• W2000941383 cites W1973949275 @default.
• W2000941383 cites W2005598290 @default.
• W2000941383 cites W2015442219 @default.
• W2000941383 cites W2024251508 @default.
• W2000941383 cites W2027119403 @default.
• W2000941383 cites W2039337370 @default.
• W2000941383 cites W2045496674 @default.
• W2000941383 cites W2046187517 @default.
• W2000941383 cites W2060800940 @default.
• W2000941383 cites W2070483336 @default.
• W2000941383 cites W2072478036 @default.
• W2000941383 cites W2085619452 @default.
• W2000941383 cites W2090810855 @default.
• W2000941383 cites W2103227841 @default.
• W2000941383 cites W2103320120 @default.
• W2000941383 cites W2120370266 @default.
• W2000941383 cites W2125106798 @default.
• W2000941383 cites W2137893932 @default.
• W2000941383 cites W2140985128 @default.
• W2000941383 cites W2152280976 @default.
• W2000941383 cites W2156877588 @default.
• W2000941383 cites W2158055057 @default.
• W2000941383 cites W2162232725 @default.
• W2000941383 cites W2163535129 @default.
• W2000941383 cites W2168520717 @default.
• W2000941383 cites W2170434596 @default.
• W2000941383 cites W2254490188 @default.
• W2000941383 cites W67799235 @default.
• W2000941383 doi "https://doi.org/10.1084/jem.157.5.1618" @default.
• W2000941383 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2186997" @default.
• W2000941383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6189942" @default.
• W2000941383 hasPublicationYear "1983" @default.
• W2000941383 type Work @default.
• W2000941383 sameAs 2000941383 @default.
• W2000941383 citedByCount "127" @default.
• W2000941383 countsByYear W20009413832014 @default.
• W2000941383 crossrefType "journal-article" @default.
• W2000941383 hasAuthorship W2000941383A5001497872 @default.
• W2000941383 hasAuthorship W2000941383A5082096834 @default.
• W2000941383 hasBestOaLocation W20009413831 @default.
• W2000941383 hasConcept C108249834 @default.
• W2000941383 hasConcept C147483822 @default.
• W2000941383 hasConcept C153911025 @default.
• W2000941383 hasConcept C170627219 @default.
• W2000941383 hasConcept C195616568 @default.
• W2000941383 hasConcept C203014093 @default.
• W2000941383 hasConcept C207936829 @default.
• W2000941383 hasConcept C2776090121 @default.
• W2000941383 hasConcept C2992881475 @default.
• W2000941383 hasConcept C67662055 @default.
• W2000941383 hasConcept C83464605 @default.
• W2000941383 hasConcept C86803240 @default.
• W2000941383 hasConcept C8891405 @default.
• W2000941383 hasConcept C95444343 @default.
• W2000941383 hasConceptScore W2000941383C108249834 @default.
• W2000941383 hasConceptScore W2000941383C147483822 @default.
• W2000941383 hasConceptScore W2000941383C153911025 @default.
• W2000941383 hasConceptScore W2000941383C170627219 @default.
• W2000941383 hasConceptScore W2000941383C195616568 @default.
• W2000941383 hasConceptScore W2000941383C203014093 @default.
• W2000941383 hasConceptScore W2000941383C207936829 @default.
• W2000941383 hasConceptScore W2000941383C2776090121 @default.
• W2000941383 hasConceptScore W2000941383C2992881475 @default.
• W2000941383 hasConceptScore W2000941383C67662055 @default.
• W2000941383 hasConceptScore W2000941383C83464605 @default.
• W2000941383 hasConceptScore W2000941383C86803240 @default.
• W2000941383 hasConceptScore W2000941383C8891405 @default.
• W2000941383 hasConceptScore W2000941383C95444343 @default.
• W2000941383 hasIssue "5" @default.
• W2000941383 hasLocation W20009413831 @default.
• W2000941383 hasLocation W20009413832 @default.
• W2000941383 hasLocation W20009413833 @default.
• W2000941383 hasLocation W20009413834 @default.
• W2000941383 hasOpenAccess W2000941383 @default.
• W2000941383 hasPrimaryLocation W20009413831 @default.
• W2000941383 hasRelatedWork W1661038996 @default.
• W2000941383 hasRelatedWork W1680198589 @default.

• next