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- W2000942152 abstract "The simultaneous measurement of tracer resorption and apposition in a rat fracture model was accomplished with 99mTc labeled methylene diphosphonate (99mTc-MDP) and 125I labeled phenylphosphonic acid (125I-øPA), respectively. Loss of 125I-øPA from the fracture site showed a biexponential release pattern; I = 31% (t12b = 2.0 d) and II = 69% (t12b = 55.4 d). 99mTc MDP temporal apposition at the fracture site followed the law of allometric growth (y = bxk) with k = 7.75, 10 days post injury. The 125I-øPA loss differed significantly (P < 0.001) when compared to normal bone which exhibits a monoexponential release with a t12b = 962 days. In the rat tibia fracture model investigated, bone apposition significantly (P < 0.001) dominates over bone resorption as a function of time. This overwhelming difference partially accounts for the healing process. The apposition-resorption comparison may be a useful index for following the course of skeletal pathology for a variety of model systems." @default.
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- W2000942152 date "1988-01-01" @default.
- W2000942152 modified "2023-09-26" @default.
- W2000942152 title "Dual tracer resorption and apposition in a rat fracture model" @default.
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- W2000942152 doi "https://doi.org/10.1016/0883-2897(88)90086-4" @default.
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