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- W2000942338 abstract "Summary Objectives An increased risk for cardiovascular disease with psoriasis has been reported. Growth Arrest‐Specific 6 ( GAS 6) amplifies pro‐inflammatory endothelial cell activation via TAM receptors. However, it also inhibits inflammation by multiple mechanisms including phagocytosis. The objective of this study was to investigate whether plasma GAS 6 levels are associated with conventional cardiometabolic ( CM ) risk factors in patients with psoriasis. Methods Forty patients diagnosed with psoriasis (22 male, mean age: 43.3 ± 13.8 years) and 40 age‐/sex‐matched healthy controls (22 male, mean age: 39.3 ± 8.9 years) were included in the study. CM risk factors (hypertension, hyperlipidemia, diabetes mellitus, and cigarette smoking) were identified. GAS 6 levels were measured by ELISA . Results There were no significant differences between the plasma GAS 6 levels of patients with psoriasis compared to the control group (6.6 ± 2.0 ng/ mL , 7.6 ± 2.8 ng/ mL , respectively, P > 0.05). However, GAS 6 levels of patients with psoriasis having a smoking history (n = 11) were significantly lower than both patients with psoriasis who had no smoking history (n = 29) and controls (5.5 ± 1.7 ng/ mL , 6.9 ± 1.9 ng/ mL , 7.6 ± 2.8 ng/ mL , respectively, P < 0.05). Similarly, psoriasis patients with at least one CM risk factor showed lower GAS 6 levels compared to subjects without any CM risk factor (5.7 ± 1.7 ng/ mL , 7.3 ± 2.0 ng/ mL , P < 0.01). There was no correlation between the GAS 6 level, disease duration or PASI score ( r = 0.150, −0.150, and P = 0.310, 0.398, respectively). Conclusions This pilot study provides the first evidence in humans for an association between low plasma GAS 6 levels and conventional risk factors in psoriasis. Further large scale, prospective studies are needed to confirm these results." @default.
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- W2000942338 date "2015-03-26" @default.
- W2000942338 modified "2023-10-05" @default.
- W2000942338 title "Growth Arrest-Specific 6 and Cardiometabolic Risk Factors in Patients with Psoriasis" @default.
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- W2000942338 doi "https://doi.org/10.1111/1755-5922.12112" @default.
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