Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000942655> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2000942655 endingPage "33" @default.
- W2000942655 startingPage "26" @default.
- W2000942655 abstract "Background: One cause of diffuse bleeding after cardiac operations may be a low plasma concentration of coagulation Factor XIII, which is essential for coagulation but is not covered by standard coagulation monitoring. Patients and Methods: In a prospective, randomized, double blinded study, 2500 units, 1250 units, and a placebo were administered in groups of 25 patients each, immediately after administration of protamine. Postoperative amount of blood loss and blood transfusion was recorded. Results: Patients were not statistically different with respect to the course of plasma levels of Factor XIII until administration of the study drug. In all groups Factor XIII fell from preoperative normal values to subnormal values after extracorporeal circulation. After administration of the study drug, Factor XIII increased to 71 %, 85 %, 103 % in the placebo, 1250 units, and 2500 units group, respectively, and these differences were statistically significant (p < 0.05). Postoperative blood loss was lowest in the 2500 units group and highest in the placebo group, however this was not significantly different. There was also no significant difference in the amount of blood transfusion. After differentiating all patients according to their post medication Factor XIII level into two groups with levels of < 70 % and ≥ 70 %, postoperative blood loss was found to be significantly higher in the < 70 % group as was the amount of blood transfusions. Conclusions: Factor XIII administration reduces postoperative blood loss and the extent of blood transfusion after coronary surgery, however administration is only helpful if plasma levels are below the normal value. Measurement of plasma levels is recommended before Factor XIII substitution." @default.
- W2000942655 created "2016-06-24" @default.
- W2000942655 creator A5013385206 @default.
- W2000942655 creator A5074814648 @default.
- W2000942655 creator A5080397094 @default.
- W2000942655 creator A5080655148 @default.
- W2000942655 creator A5082291191 @default.
- W2000942655 date "2006-02-01" @default.
- W2000942655 modified "2023-10-16" @default.
- W2000942655 title "Coagulation Factor XIII Reduces Postoperative Bleeding After Coronary Surgery with Extracorporeal Circulation" @default.
- W2000942655 doi "https://doi.org/10.1055/s-2005-872853" @default.
- W2000942655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16485185" @default.
- W2000942655 hasPublicationYear "2006" @default.
- W2000942655 type Work @default.
- W2000942655 sameAs 2000942655 @default.
- W2000942655 citedByCount "119" @default.
- W2000942655 countsByYear W20009426552012 @default.
- W2000942655 countsByYear W20009426552013 @default.
- W2000942655 countsByYear W20009426552014 @default.
- W2000942655 countsByYear W20009426552015 @default.
- W2000942655 countsByYear W20009426552016 @default.
- W2000942655 countsByYear W20009426552017 @default.
- W2000942655 countsByYear W20009426552018 @default.
- W2000942655 countsByYear W20009426552019 @default.
- W2000942655 countsByYear W20009426552020 @default.
- W2000942655 countsByYear W20009426552021 @default.
- W2000942655 countsByYear W20009426552022 @default.
- W2000942655 countsByYear W20009426552023 @default.
- W2000942655 crossrefType "journal-article" @default.
- W2000942655 hasAuthorship W2000942655A5013385206 @default.
- W2000942655 hasAuthorship W2000942655A5074814648 @default.
- W2000942655 hasAuthorship W2000942655A5080397094 @default.
- W2000942655 hasAuthorship W2000942655A5080655148 @default.
- W2000942655 hasAuthorship W2000942655A5082291191 @default.
- W2000942655 hasConcept C126322002 @default.
- W2000942655 hasConcept C141071460 @default.
- W2000942655 hasConcept C142724271 @default.
- W2000942655 hasConcept C204787440 @default.
- W2000942655 hasConcept C27081682 @default.
- W2000942655 hasConcept C2778382381 @default.
- W2000942655 hasConcept C2780014101 @default.
- W2000942655 hasConcept C2994232697 @default.
- W2000942655 hasConcept C42219234 @default.
- W2000942655 hasConcept C71924100 @default.
- W2000942655 hasConceptScore W2000942655C126322002 @default.
- W2000942655 hasConceptScore W2000942655C141071460 @default.
- W2000942655 hasConceptScore W2000942655C142724271 @default.
- W2000942655 hasConceptScore W2000942655C204787440 @default.
- W2000942655 hasConceptScore W2000942655C27081682 @default.
- W2000942655 hasConceptScore W2000942655C2778382381 @default.
- W2000942655 hasConceptScore W2000942655C2780014101 @default.
- W2000942655 hasConceptScore W2000942655C2994232697 @default.
- W2000942655 hasConceptScore W2000942655C42219234 @default.
- W2000942655 hasConceptScore W2000942655C71924100 @default.
- W2000942655 hasIssue "1" @default.
- W2000942655 hasLocation W20009426551 @default.
- W2000942655 hasLocation W20009426552 @default.
- W2000942655 hasOpenAccess W2000942655 @default.
- W2000942655 hasPrimaryLocation W20009426551 @default.
- W2000942655 hasRelatedWork W2002120878 @default.
- W2000942655 hasRelatedWork W2003938723 @default.
- W2000942655 hasRelatedWork W2047967234 @default.
- W2000942655 hasRelatedWork W2118496982 @default.
- W2000942655 hasRelatedWork W2364998975 @default.
- W2000942655 hasRelatedWork W2414737285 @default.
- W2000942655 hasRelatedWork W2439875401 @default.
- W2000942655 hasRelatedWork W4238867864 @default.
- W2000942655 hasRelatedWork W2519357708 @default.
- W2000942655 hasRelatedWork W2525756941 @default.
- W2000942655 hasVolume "54" @default.
- W2000942655 isParatext "false" @default.
- W2000942655 isRetracted "false" @default.
- W2000942655 magId "2000942655" @default.
- W2000942655 workType "article" @default.