FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000943303> ?p ?o ?g. }

• W2000943303 endingPage "1649" @default.
• W2000943303 startingPage "1649" @default.
• W2000943303 abstract "<h3>Background</h3> The small-conductance calcium-activated potassium channel gene (<i>hSKCa3</i>) contains 2 CAG repeats, 1 of which is highly polymorphic. Although this repeat is not pathologically expanded in patients with schizophrenia, some studies have suggested an allelic association with schizophrenia. CAG expansions in other genes such as the α1 subunit of a brain-specific P/Q-type calcium channel gene cause spinocerebellar ataxia type 6, whereas the length of the CAG repeat in the<i>RAI1</i>gene modifies the age of onset of spinocerebellar ataxia type 2. <h3>Objectives</h3> To evaluate expansions in the<i>hSKCa3</i>polyglutamine domain as causative for ataxia, and to study the association between the length of the polyglutamine repeat and the presence of ataxia. <h3>Methods</h3> We analyzed this repeat in 122 patients with autosomal dominant cerebellar ataxia, or sporadic ataxia, and compared allele distribution with 750 alleles seen in 2 healthy control groups and 172 alleles in patients with Parkinson disease. <h3>Results</h3> The distribution of alleles in ataxia patients and controls was significantly different by Wilcoxon rank test (<i>P</i><.001). Twenty-two or more polyglutamine tracts were more common in ataxia patients compared with controls by χ²analysis (<i>P</i><.001). <h3>Conclusion</h3> Longer stretches of polyglutamines in a human potassium channel are not causative for ataxia, but they are associated with the presence of ataxia. There is no association with the presence of Parkinson disease." @default.
• W2000943303 created "2016-06-24" @default.
• W2000943303 creator A5014464711 @default.
• W2000943303 creator A5018481303 @default.
• W2000943303 creator A5043106734 @default.
• W2000943303 creator A5050112775 @default.
• W2000943303 creator A5056686380 @default.
• W2000943303 creator A5062320618 @default.
• W2000943303 creator A5076004371 @default.
• W2000943303 creator A5091346458 @default.
• W2000943303 date "2001-10-01" @default.
• W2000943303 modified "2023-09-25" @default.
• W2000943303 title "Association of Moderate Polyglutamine Tract Expansions in the Slow Calcium-Activated Potassium Channel Type 3 With Ataxia" @default.
• W2000943303 cites W1569018103 @default.
• W2000943303 cites W1964730293 @default.
• W2000943303 cites W1965271056 @default.
• W2000943303 cites W1965321873 @default.
• W2000943303 cites W1971047357 @default.
• W2000943303 cites W1985866397 @default.
• W2000943303 cites W1985958365 @default.
• W2000943303 cites W1989178832 @default.
• W2000943303 cites W2016082167 @default.
• W2000943303 cites W2020206460 @default.
• W2000943303 cites W2025197615 @default.
• W2000943303 cites W2031425761 @default.
• W2000943303 cites W2042365084 @default.
• W2000943303 cites W2046505827 @default.
• W2000943303 cites W2051908155 @default.
• W2000943303 cites W2053009171 @default.
• W2000943303 cites W2064551580 @default.
• W2000943303 cites W2070704449 @default.
• W2000943303 cites W2071309382 @default.
• W2000943303 cites W2075338220 @default.
• W2000943303 cites W2085137305 @default.
• W2000943303 cites W2107170683 @default.
• W2000943303 cites W2119887971 @default.
• W2000943303 cites W2170670132 @default.
• W2000943303 cites W2171917143 @default.
• W2000943303 cites W2333485770 @default.
• W2000943303 cites W2769888961 @default.
• W2000943303 cites W2917115110 @default.
• W2000943303 cites W3080688864 @default.
• W2000943303 doi "https://doi.org/10.1001/archneur.58.10.1649" @default.
• W2000943303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11594924" @default.
• W2000943303 hasPublicationYear "2001" @default.
• W2000943303 type Work @default.
• W2000943303 sameAs 2000943303 @default.
• W2000943303 citedByCount "21" @default.
• W2000943303 countsByYear W20009433032012 @default.
• W2000943303 countsByYear W20009433032013 @default.
• W2000943303 countsByYear W20009433032018 @default.
• W2000943303 countsByYear W20009433032022 @default.
• W2000943303 countsByYear W20009433032023 @default.
• W2000943303 crossrefType "journal-article" @default.
• W2000943303 hasAuthorship W2000943303A5014464711 @default.
• W2000943303 hasAuthorship W2000943303A5018481303 @default.
• W2000943303 hasAuthorship W2000943303A5043106734 @default.
• W2000943303 hasAuthorship W2000943303A5050112775 @default.
• W2000943303 hasAuthorship W2000943303A5056686380 @default.
• W2000943303 hasAuthorship W2000943303A5062320618 @default.
• W2000943303 hasAuthorship W2000943303A5076004371 @default.
• W2000943303 hasAuthorship W2000943303A5091346458 @default.
• W2000943303 hasBestOaLocation W20009433031 @default.
• W2000943303 hasConcept C104317684 @default.
• W2000943303 hasConcept C126322002 @default.
• W2000943303 hasConcept C134018914 @default.
• W2000943303 hasConcept C169760540 @default.
• W2000943303 hasConcept C180754005 @default.
• W2000943303 hasConcept C2779500118 @default.
• W2000943303 hasConcept C2780148635 @default.
• W2000943303 hasConcept C2780906641 @default.
• W2000943303 hasConcept C54355233 @default.
• W2000943303 hasConcept C71924100 @default.
• W2000943303 hasConcept C86803240 @default.
• W2000943303 hasConceptScore W2000943303C104317684 @default.
• W2000943303 hasConceptScore W2000943303C126322002 @default.
• W2000943303 hasConceptScore W2000943303C134018914 @default.
• W2000943303 hasConceptScore W2000943303C169760540 @default.
• W2000943303 hasConceptScore W2000943303C180754005 @default.
• W2000943303 hasConceptScore W2000943303C2779500118 @default.
• W2000943303 hasConceptScore W2000943303C2780148635 @default.
• W2000943303 hasConceptScore W2000943303C2780906641 @default.
• W2000943303 hasConceptScore W2000943303C54355233 @default.
• W2000943303 hasConceptScore W2000943303C71924100 @default.
• W2000943303 hasConceptScore W2000943303C86803240 @default.
• W2000943303 hasIssue "10" @default.
• W2000943303 hasLocation W20009433031 @default.
• W2000943303 hasLocation W20009433032 @default.
• W2000943303 hasOpenAccess W2000943303 @default.
• W2000943303 hasPrimaryLocation W20009433031 @default.
• W2000943303 hasRelatedWork W1970972148 @default.
• W2000943303 hasRelatedWork W2042083515 @default.
• W2000943303 hasRelatedWork W2057739827 @default.
• W2000943303 hasRelatedWork W2074314222 @default.
• W2000943303 hasRelatedWork W2074406236 @default.
• W2000943303 hasRelatedWork W2084274029 @default.
• W2000943303 hasRelatedWork W2100137986 @default.
• W2000943303 hasRelatedWork W2314216981 @default.

• next