Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000948609> ?p ?o ?g. }
- W2000948609 endingPage "792" @default.
- W2000948609 startingPage "786" @default.
- W2000948609 abstract "Summary. Heparin‐induced thrombocytopenia (HIT) is a common adverse effect of unfractionated heparin (UFH) therapy. In contrast, only a few patients have been reported with HIT following low‐molecular‐weight heparin (LMWH) therapy (LMW‐HIT). To define the clinical and biological characteristics of LMW‐HIT, 180 patients treated for suspected HIT at 15 French centres were investigated. Clinical history was recorded and HIT was confirmed in 59 patients with positive serotonin release assay results: 57 of them had high levels of antibodies (Abs) to heparin–platelet factor 4 complexes (H/PF4) and two had Abs to interleukin 8. Eleven patients were treated exclusively with LMWH (LMW‐HIT) and 48 with UFH either alone (UF‐HIT, n = 34) or combined with LMWH (UF/LMW‐HIT, n = 14). The LMW‐HIT and UF‐HIT groups were similar with respect to sex, age, platelet count before heparin therapy, frequency of bleeding and occurrence of disseminated intravascular coagulation. The interval to onset of HIT was longer in LMW‐HIT patients compared with UF‐HIT patients ( P = 0·03). Severe thrombocytopenia (platelets < 15 × 10 9 /l) was more frequent in the LMW‐HIT group ( P = 0·04). Thrombosis occurred in three of 11 LMW‐HIT patients, i.e. as frequently as in UF‐HIT patients. LMW‐HIT is potentially severe and may be observed after longer heparin treatment compared with UF‐HIT. It is highly recommended, therefore, that platelet counts be monitored carefully whenever LMWH is administered." @default.
- W2000948609 created "2016-06-24" @default.
- W2000948609 creator A5013650708 @default.
- W2000948609 creator A5014311227 @default.
- W2000948609 creator A5018171524 @default.
- W2000948609 creator A5027946272 @default.
- W2000948609 creator A5042433763 @default.
- W2000948609 creator A5059037990 @default.
- W2000948609 creator A5070086202 @default.
- W2000948609 creator A5089541378 @default.
- W2000948609 date "2003-05-28" @default.
- W2000948609 modified "2023-10-17" @default.
- W2000948609 title "Biological and clinical features of low-molecular-weight heparin-induced thrombocytopenia" @default.
- W2000948609 cites W108425301 @default.
- W2000948609 cites W116242010 @default.
- W2000948609 cites W1528158334 @default.
- W2000948609 cites W1892579436 @default.
- W2000948609 cites W1930976597 @default.
- W2000948609 cites W1982393004 @default.
- W2000948609 cites W2019564899 @default.
- W2000948609 cites W2043292703 @default.
- W2000948609 cites W2051399352 @default.
- W2000948609 cites W2053593414 @default.
- W2000948609 cites W2070676143 @default.
- W2000948609 cites W2076315269 @default.
- W2000948609 cites W2082782226 @default.
- W2000948609 cites W2083317390 @default.
- W2000948609 cites W2092170166 @default.
- W2000948609 cites W2092772310 @default.
- W2000948609 cites W2099343392 @default.
- W2000948609 cites W2116442335 @default.
- W2000948609 cites W2138600840 @default.
- W2000948609 cites W2287518913 @default.
- W2000948609 cites W2316071283 @default.
- W2000948609 cites W2318484070 @default.
- W2000948609 cites W2333983635 @default.
- W2000948609 doi "https://doi.org/10.1046/j.1365-2141.2003.04363.x" @default.
- W2000948609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12780795" @default.
- W2000948609 hasPublicationYear "2003" @default.
- W2000948609 type Work @default.
- W2000948609 sameAs 2000948609 @default.
- W2000948609 citedByCount "98" @default.
- W2000948609 countsByYear W20009486092012 @default.
- W2000948609 countsByYear W20009486092013 @default.
- W2000948609 countsByYear W20009486092014 @default.
- W2000948609 countsByYear W20009486092015 @default.
- W2000948609 countsByYear W20009486092016 @default.
- W2000948609 countsByYear W20009486092018 @default.
- W2000948609 countsByYear W20009486092019 @default.
- W2000948609 countsByYear W20009486092020 @default.
- W2000948609 countsByYear W20009486092021 @default.
- W2000948609 countsByYear W20009486092022 @default.
- W2000948609 countsByYear W20009486092023 @default.
- W2000948609 crossrefType "journal-article" @default.
- W2000948609 hasAuthorship W2000948609A5013650708 @default.
- W2000948609 hasAuthorship W2000948609A5014311227 @default.
- W2000948609 hasAuthorship W2000948609A5018171524 @default.
- W2000948609 hasAuthorship W2000948609A5027946272 @default.
- W2000948609 hasAuthorship W2000948609A5042433763 @default.
- W2000948609 hasAuthorship W2000948609A5059037990 @default.
- W2000948609 hasAuthorship W2000948609A5070086202 @default.
- W2000948609 hasAuthorship W2000948609A5089541378 @default.
- W2000948609 hasConcept C126322002 @default.
- W2000948609 hasConcept C141071460 @default.
- W2000948609 hasConcept C159973064 @default.
- W2000948609 hasConcept C197934379 @default.
- W2000948609 hasConcept C2776472838 @default.
- W2000948609 hasConcept C2776884760 @default.
- W2000948609 hasConcept C2777557582 @default.
- W2000948609 hasConcept C2778382381 @default.
- W2000948609 hasConcept C2778734968 @default.
- W2000948609 hasConcept C2780868729 @default.
- W2000948609 hasConcept C71924100 @default.
- W2000948609 hasConcept C89560881 @default.
- W2000948609 hasConcept C90924648 @default.
- W2000948609 hasConceptScore W2000948609C126322002 @default.
- W2000948609 hasConceptScore W2000948609C141071460 @default.
- W2000948609 hasConceptScore W2000948609C159973064 @default.
- W2000948609 hasConceptScore W2000948609C197934379 @default.
- W2000948609 hasConceptScore W2000948609C2776472838 @default.
- W2000948609 hasConceptScore W2000948609C2776884760 @default.
- W2000948609 hasConceptScore W2000948609C2777557582 @default.
- W2000948609 hasConceptScore W2000948609C2778382381 @default.
- W2000948609 hasConceptScore W2000948609C2778734968 @default.
- W2000948609 hasConceptScore W2000948609C2780868729 @default.
- W2000948609 hasConceptScore W2000948609C71924100 @default.
- W2000948609 hasConceptScore W2000948609C89560881 @default.
- W2000948609 hasConceptScore W2000948609C90924648 @default.
- W2000948609 hasIssue "5" @default.
- W2000948609 hasLocation W20009486091 @default.
- W2000948609 hasLocation W20009486092 @default.
- W2000948609 hasOpenAccess W2000948609 @default.
- W2000948609 hasPrimaryLocation W20009486091 @default.
- W2000948609 hasRelatedWork W1613605883 @default.
- W2000948609 hasRelatedWork W2000250009 @default.
- W2000948609 hasRelatedWork W2023022634 @default.
- W2000948609 hasRelatedWork W2079842229 @default.
- W2000948609 hasRelatedWork W2171794980 @default.