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- W2000948800 abstract "The acute haemodynamic effects of 40 mg isosorbide dinitrate (10 subjects), 4 mg prazosin (20 subjects) and 50 mg dihydralazine (8 subjects) were compared in 24 patients with the clinical picture of chronic therapy-resistant cardiac failure (NY Heart Association stages III-IV). There was a fall in left-ventricular filling pressure of about 15% and right-atrial mean pressure of 21 and 24%, respectively, with isosorbide dinitrate and prazosin, while there was no change with dihydralazine. Cardiac output rose by 23% with dihydralazine and 20% with prazosin, but remained unchanged with isosorbide dinitrate. These data indicate that a reduction in pulmonary and systemic-venous congestion due to chronic decompensated cardiac failure can be achieved with isosorbide dinitrate and prazosin, while cardiac output can be improved only with prazosin and dihydralazine." @default.
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- W2000948800 date "2008-03-26" @default.
- W2000948800 modified "2023-10-06" @default.
- W2000948800 title "Oral wirksame Vasodilatoren bei der chronischen therapieresistenten Herzinsuffizienz: Wirkungsvergleich von Isosorbiddinitrat, Prazosin und Dihydralazin" @default.
- W2000948800 doi "https://doi.org/10.1055/s-2008-1070875" @default.
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