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- W2000950324 abstract "Long term potentiation (LTP) of synaptic transmission has been considered a cellular mechanism for learning and memory. Pharmacological blockade of synaptic receptors or recent gene-targeting approaches gave evidence to support the hypothesis. However, modifiable synapses are generally embedded deep in complex circuits and many neurons participate in a learning behavior. We first demonstrated a link between LTP and behavioral learning by using a simple circuit for goldfish escape behavior: a single spike of one of the paired Mauthner cells in hindbrain initiates the fast escape response. Repeated sound stimuli to the fish induce LTP of the feedforward inhibition of the M-cell from the auditory nerve and long-lasting desensitization of the escape behavior." @default.
- W2000950324 created "2016-06-24" @default.
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- W2000950324 date "2001-01-01" @default.
- W2000950324 modified "2023-09-26" @default.
- W2000950324 title "LTP as a Cellular Basis for Learning and Memory." @default.
- W2000950324 doi "https://doi.org/10.2142/biophys.41.80" @default.
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