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- W2000950416 abstract "Background: Although the precise pathophysiology that leads to placental abruption is unknown, there is evidence supporting a genetic etiology. Methods: We searched PubMed and systematically reviewed all case-control studies that investigated the association between genetic variants and placental abruption. Pooled genetic risks were estimated using fixed and random effects odds ratios. Results: Twenty-two articles, examining a total of 14 gene polymorphisms were identified. Seven polymorphisms (F5 Arg506Gln, F5 Met385Thr, F2 G20210A, MTHFR A1298C, MTHFD1 Arg653Gln, NOS3 Glu298Asp, AGT Met235Thr) show significant association in individual studies. Six of the 7 (all except F5Met385Thr) were studied more than once and we therefore included them in our meta-analyses. A positive association under the dominant model was found for the F5 Arg506Gln and F2 G20210A polymorphisms. The random-effects odds ratio for the F5 Arg506Gln polymorphism was 3.4 (95% confidence interval = 1.4–8.3) and the fixed-effects odds ratio for the F2 G20210A polymorphism was 6.7 (3.2–13). Conclusion: Considering the multifactorial etiology of abruption and the relatively small numbers of studies and participants, this review provides only the first clues of possible genetic causes. Larger case-control studies that include gene-gene and gene-environment interactions may help to elucidate the genetics of placental abruption further." @default.
- W2000950416 created "2016-06-24" @default.
- W2000950416 creator A5006346169 @default.
- W2000950416 creator A5019002791 @default.
- W2000950416 date "2008-03-01" @default.
- W2000950416 modified "2023-09-25" @default.
- W2000950416 title "Genetic Risk Factors for Placental Abruption" @default.
- W2000950416 cites W1531281563 @default.
- W2000950416 cites W1551600243 @default.
- W2000950416 cites W1943433312 @default.
- W2000950416 cites W1965208069 @default.
- W2000950416 cites W1965958910 @default.
- W2000950416 cites W1966059603 @default.
- W2000950416 cites W1966251853 @default.
- W2000950416 cites W1966563925 @default.
- W2000950416 cites W1967162645 @default.
- W2000950416 cites W1968409334 @default.
- W2000950416 cites W1968776100 @default.
- W2000950416 cites W1970267124 @default.
- W2000950416 cites W1972561326 @default.
- W2000950416 cites W1976555550 @default.
- W2000950416 cites W1976692614 @default.
- W2000950416 cites W1976957654 @default.
- W2000950416 cites W1977496127 @default.
- W2000950416 cites W1979599639 @default.
- W2000950416 cites W1980952325 @default.
- W2000950416 cites W1980955882 @default.
- W2000950416 cites W1983879434 @default.
- W2000950416 cites W1984052321 @default.
- W2000950416 cites W1985094403 @default.
- W2000950416 cites W1988892839 @default.
- W2000950416 cites W1991956048 @default.
- W2000950416 cites W1996465975 @default.
- W2000950416 cites W2000755598 @default.
- W2000950416 cites W2001274648 @default.
- W2000950416 cites W2006179809 @default.
- W2000950416 cites W2011987261 @default.
- W2000950416 cites W2018973645 @default.
- W2000950416 cites W2024267714 @default.
- W2000950416 cites W2029415871 @default.
- W2000950416 cites W2030223911 @default.
- W2000950416 cites W2030946046 @default.
- W2000950416 cites W2034745515 @default.
- W2000950416 cites W2035137312 @default.
- W2000950416 cites W2037051824 @default.
- W2000950416 cites W2041094959 @default.
- W2000950416 cites W2048640604 @default.
- W2000950416 cites W2049682361 @default.
- W2000950416 cites W2050809423 @default.
- W2000950416 cites W2051054384 @default.
- W2000950416 cites W2054817429 @default.
- W2000950416 cites W2057550630 @default.
- W2000950416 cites W2062251724 @default.
- W2000950416 cites W2066412142 @default.
- W2000950416 cites W2066634394 @default.
- W2000950416 cites W2073264424 @default.
- W2000950416 cites W2073576373 @default.
- W2000950416 cites W2075166505 @default.
- W2000950416 cites W2077550989 @default.
- W2000950416 cites W2078911886 @default.
- W2000950416 cites W2083821800 @default.
- W2000950416 cites W2089007687 @default.
- W2000950416 cites W2092086758 @default.
- W2000950416 cites W2092795482 @default.
- W2000950416 cites W2093078663 @default.
- W2000950416 cites W2105515856 @default.
- W2000950416 cites W2107328434 @default.
- W2000950416 cites W2110068024 @default.
- W2000950416 cites W2113034203 @default.
- W2000950416 cites W2116329478 @default.
- W2000950416 cites W2118714009 @default.
- W2000950416 cites W2120739842 @default.
- W2000950416 cites W2122732537 @default.
- W2000950416 cites W2123213735 @default.
- W2000950416 cites W2124096767 @default.
- W2000950416 cites W2125435699 @default.
- W2000950416 cites W2125858955 @default.
- W2000950416 cites W2133795217 @default.
- W2000950416 cites W2136594582 @default.
- W2000950416 cites W2140735246 @default.
- W2000950416 cites W2142075862 @default.
- W2000950416 cites W2144891453 @default.
- W2000950416 cites W2147082874 @default.
- W2000950416 cites W2151566559 @default.
- W2000950416 cites W2153151900 @default.
- W2000950416 cites W2165715420 @default.
- W2000950416 cites W2166474378 @default.
- W2000950416 cites W2169259236 @default.
- W2000950416 cites W2217809488 @default.
- W2000950416 cites W2338236627 @default.
- W2000950416 cites W24088030 @default.
- W2000950416 cites W2461347464 @default.
- W2000950416 cites W4230179042 @default.
- W2000950416 cites W4238604759 @default.
- W2000950416 cites W4244302144 @default.
- W2000950416 cites W4253370572 @default.
- W2000950416 cites W4302066926 @default.
- W2000950416 cites W4384491005 @default.