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• W2000951010 endingPage "10280" @default.
• W2000951010 startingPage "10270" @default.
• W2000951010 abstract "Postsynaptic alterations have been suggested to account for NMDA receptor (NMDAR)-dependent long-term depression (LTD) and long-term potentiation of synaptic strength, although there is substantial evidence supporting changes in presynaptic release. Direct chemical activation of either NMDA or group I metabotropic glutamate receptor (mGluR1) elicits LTD of similar magnitudes, but it is unknown whether they share common expression mechanisms. Using dual-photon laser-scanning microscopy of FM1-43 [ N -(3-triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide] to directly visualize presynaptic vesicular release from the rapidly recycling vesicle pool (RRP) at Schaffer collateral terminals in field CA1 of rat hippocampal slices, we found that a persistent reduction in vesicular release from the RRP is induced by NMDA-LTD but not by mGluR1-LTD. Variance-mean analyses of Schaffer collateral release probability ( P r ) at varying extracellular calcium concentrations confirmed that NMDA-LTD was associated with reduced P r , whereas mGluR1-LTD was not. Pharmacological isolation of NMDAR-dependent and mGluR-dependent forms of stimulus-evoked LTD revealed that both are composed of a combination of presynaptic and postsynaptic alterations. However, when group I mGluR-dependent LTD was isolated by combining an NMDAR blocker with a group II mGluR antagonist, this form of LTD was purely postsynaptic. The nitric oxide synthase inhibitor Nω-nitro- l -arginine blocked the induction of NMDA-LTD but did not alter mGluR-LTD, consistent with a selective role for nitric oxide as a retrograde messenger mediating NMDA-LTD. These data demonstrate that single synapses can express multiple forms of LTD with different sites of expression, that NMDA-LTD is a combination of presynaptic and postsynaptic alterations, but that group I mGluR-LTD appears to be expressed entirely postsynaptically." @default.
• W2000951010 created "2016-06-24" @default.
• W2000951010 creator A5001733833 @default.
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• W2000951010 creator A5058193642 @default.
• W2000951010 creator A5082846858 @default.
• W2000951010 date "2006-10-04" @default.
• W2000951010 modified "2023-10-12" @default.
• W2000951010 title "NMDA-Dependent, But Not Group I Metabotropic Glutamate Receptor-Dependent, Long-Term Depression at Schaffer Collateral–CA1 Synapses Is Associated with Long-Term Reduction of Release from the Rapidly Recycling Presynaptic Vesicle Pool" @default.
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• W2000951010 doi "https://doi.org/10.1523/jneurosci.3091-06.2006" @default.
• W2000951010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674623" @default.
• W2000951010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17021182" @default.
• W2000951010 hasPublicationYear "2006" @default.
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