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- W2000951422 abstract "Membrane binding sites for peanut lectin or peanut agglutinin (PNA) were investigated in the established mammary carcinoma cell lines MCF-7, 734-B, ZR-75.1 and BT-20. The determination of PNA binding sites was performed in a flow cytometer after staining with fluoreseein(FITC)-labeled PNA. It appeared that only the estrogen-sensitive cell lines exhibited PNA binding sites, whereas the hormoneinsensitive cell line BT-20 was clearly negative. Steroid hormones, when administered singly to the cells in physiological concentrations (10−9−10−8m) had no effect on PNA binding expression. Only the combination of estradiol and progesterone together increased PNA binding sites. Pharmacological doses (10−6M) of medroxyprogesteroneacetate (MPA) and dexamethasone increased the number of binding sites, whereas retinoic acid decreased them. A preliminary characterization of the binding sites revealed that they have high capacity and moderate affinity for PNA (KD > 10−7 M). FITC-PNA binding could be inhibited selectively by fetuin (> 10−5 M) and by galactose (> 10−2 M). Cytosol from MCF-7 cells and from some primary breast cancer specimens were able to decrease PNA binding to the surface of 734-B cells." @default.
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- W2000951422 date "1986-01-01" @default.
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- W2000951422 title "Influence of steroids and retinoic acid on peanut-lectin binding of human breast cancer cells" @default.
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- W2000951422 doi "https://doi.org/10.1016/0022-4731(86)90040-3" @default.
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