Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000952209> ?p ?o ?g. }
- W2000952209 endingPage "320" @default.
- W2000952209 startingPage "311" @default.
- W2000952209 abstract "Our objective was to establish a nonhuman primate model of perinatal asphyxia appropriate for preclinical evaluation of neuroprotective treatment strategies under conditions that closely resemble human neonatal emergencies, and to begin testing the safety and efficacy of erythropoietin neuroprotective treatment. Prior to delivery by hysterotomy, the umbilical cords of near term Macaca nemestrina (n = 8) were clamped for times ranging between 12 and 15 min. Animals received erythropoietin (5,000 U/kg/dose x 2 i.v., n = 3), or vehicle (n = 5) after resuscitation. We assessed physiologic parameters, continuous electroencephalogram, magnetic resonance imaging/spectroscopy, safety parameters and behavior. Animals were euthanized at 4 months of age. Mean birth weight was 507 +/- 62 g. Initial arterial pH ranged from 6.75 to 7.12, with base deficits of 17-25 mEq. Animals were flaccid at birth, with attenuated electroencephalograms, and seizures occurred in 3 of 8 animals. We demonstrated magnetic resonance imaging/spectroscopy changes consistent with hypoxia (elevated lactate levels were present in some animals), significant motor and behavioral abnormalities (particularly with 15 min of cord clamping), and evidence of gliosis at the time of death. We have established a reproducible model of moderate to severe perinatal hypoxic-ischemic injury in M. nemestrina newborns. This model, which combines structural, biochemical, and behavioral assessments over time can be used to assess the safety and efficacy of neuroprotective strategies." @default.
- W2000952209 created "2016-06-24" @default.
- W2000952209 creator A5010644944 @default.
- W2000952209 creator A5018516255 @default.
- W2000952209 creator A5022222794 @default.
- W2000952209 creator A5023483036 @default.
- W2000952209 creator A5027729294 @default.
- W2000952209 creator A5030468874 @default.
- W2000952209 date "2007-01-01" @default.
- W2000952209 modified "2023-10-08" @default.
- W2000952209 title "Prenatal Cord Clamping in Newborn <i>Macaca nemestrina:</i> A Model of Perinatal Asphyxia" @default.
- W2000952209 cites W107131744 @default.
- W2000952209 cites W118687360 @default.
- W2000952209 cites W142643488 @default.
- W2000952209 cites W1500700675 @default.
- W2000952209 cites W189747386 @default.
- W2000952209 cites W191246466 @default.
- W2000952209 cites W1964327177 @default.
- W2000952209 cites W1964796026 @default.
- W2000952209 cites W1965316832 @default.
- W2000952209 cites W1972290632 @default.
- W2000952209 cites W1993260341 @default.
- W2000952209 cites W1996560509 @default.
- W2000952209 cites W1997652091 @default.
- W2000952209 cites W1998121788 @default.
- W2000952209 cites W2006610691 @default.
- W2000952209 cites W2013372456 @default.
- W2000952209 cites W2014922761 @default.
- W2000952209 cites W2019091990 @default.
- W2000952209 cites W2034531079 @default.
- W2000952209 cites W2035546454 @default.
- W2000952209 cites W2036685176 @default.
- W2000952209 cites W2037722898 @default.
- W2000952209 cites W2038979894 @default.
- W2000952209 cites W2067157860 @default.
- W2000952209 cites W2068423530 @default.
- W2000952209 cites W2073078656 @default.
- W2000952209 cites W2075172177 @default.
- W2000952209 cites W2075587399 @default.
- W2000952209 cites W2081087085 @default.
- W2000952209 cites W2083865676 @default.
- W2000952209 cites W2088157162 @default.
- W2000952209 cites W2088167851 @default.
- W2000952209 cites W2094944281 @default.
- W2000952209 cites W2097474842 @default.
- W2000952209 cites W2102170106 @default.
- W2000952209 cites W2109788848 @default.
- W2000952209 cites W2110601491 @default.
- W2000952209 cites W2122965222 @default.
- W2000952209 cites W2135122869 @default.
- W2000952209 cites W2136760124 @default.
- W2000952209 cites W2136967026 @default.
- W2000952209 cites W2142463112 @default.
- W2000952209 cites W2163103034 @default.
- W2000952209 cites W2164127547 @default.
- W2000952209 cites W2165849169 @default.
- W2000952209 cites W2288990136 @default.
- W2000952209 cites W2327022395 @default.
- W2000952209 cites W2396771107 @default.
- W2000952209 cites W2403980932 @default.
- W2000952209 cites W2413676782 @default.
- W2000952209 doi "https://doi.org/10.1159/000105472" @default.
- W2000952209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17762199" @default.
- W2000952209 hasPublicationYear "2007" @default.
- W2000952209 type Work @default.
- W2000952209 sameAs 2000952209 @default.
- W2000952209 citedByCount "46" @default.
- W2000952209 countsByYear W20009522092012 @default.
- W2000952209 countsByYear W20009522092013 @default.
- W2000952209 countsByYear W20009522092014 @default.
- W2000952209 countsByYear W20009522092015 @default.
- W2000952209 countsByYear W20009522092016 @default.
- W2000952209 countsByYear W20009522092017 @default.
- W2000952209 countsByYear W20009522092018 @default.
- W2000952209 countsByYear W20009522092020 @default.
- W2000952209 countsByYear W20009522092021 @default.
- W2000952209 countsByYear W20009522092022 @default.
- W2000952209 countsByYear W20009522092023 @default.
- W2000952209 crossrefType "journal-article" @default.
- W2000952209 hasAuthorship W2000952209A5010644944 @default.
- W2000952209 hasAuthorship W2000952209A5018516255 @default.
- W2000952209 hasAuthorship W2000952209A5022222794 @default.
- W2000952209 hasAuthorship W2000952209A5023483036 @default.
- W2000952209 hasAuthorship W2000952209A5027729294 @default.
- W2000952209 hasAuthorship W2000952209A5030468874 @default.
- W2000952209 hasConcept C126322002 @default.
- W2000952209 hasConcept C178790620 @default.
- W2000952209 hasConcept C185592680 @default.
- W2000952209 hasConcept C25498285 @default.
- W2000952209 hasConcept C2778534260 @default.
- W2000952209 hasConcept C2779914510 @default.
- W2000952209 hasConcept C2780164069 @default.
- W2000952209 hasConcept C42219234 @default.
- W2000952209 hasConcept C42407357 @default.
- W2000952209 hasConcept C540031477 @default.
- W2000952209 hasConcept C71924100 @default.
- W2000952209 hasConcept C7836513 @default.
- W2000952209 hasConceptScore W2000952209C126322002 @default.