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- W2000953040 abstract "In Drosophila, XX embryos are fated to develop as females, and XY embryos as males, because the diplo-X dose of four X-linked signal element genes, XSEs, activates the Sex-lethal establishment promoter, SxlPe, whereas the haplo-X XSE dose leaves SxlPe off. The threshold response of SxlPe to XSE concentrations depends in part on the bHLH repressor, Deadpan, present in equal amounts in XX and XY embryos. We identified canonical and non-canonical DNA-binding sites for Dpn at SxlPe and found that cis-acting mutations in the Dpn-binding sites caused stronger and earlier Sxl expression than did deletion of dpn implicating other bHLH repressors in Sxl regulation. Maternal Hey encodes one such bHLH regulator but the E(spl) locus does not. Elimination of the maternal corepressor Groucho also caused strong ectopic Sxl expression in XY, and premature Sxl activation in XX embryos, but Sxl was still expressed differently in the sexes. Our findings suggest that Groucho and associated maternal and zygotic bHLH repressors define the threshold XSE concentrations needed to activate SxlPe and that they participate directly in sex signal amplification. We present a model in which the XSE signal is amplified by a feedback mechanism that interferes with Gro-mediated repression in XX, but not XY embryos." @default.
- W2000953040 created "2016-06-24" @default.
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- W2000953040 date "2008-11-01" @default.
- W2000953040 modified "2023-09-25" @default.
- W2000953040 title "Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination" @default.
- W2000953040 cites W1819790915 @default.
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- W2000953040 cites W1920945986 @default.
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- W2000953040 cites W1939300869 @default.
- W2000953040 cites W1942696207 @default.
- W2000953040 cites W1957869816 @default.
- W2000953040 cites W1976819471 @default.
- W2000953040 cites W1977186059 @default.
- W2000953040 cites W1984688123 @default.
- W2000953040 cites W1986457767 @default.
- W2000953040 cites W1990068727 @default.
- W2000953040 cites W1993827187 @default.
- W2000953040 cites W1994964287 @default.
- W2000953040 cites W2006198904 @default.
- W2000953040 cites W2007038051 @default.
- W2000953040 cites W2013740909 @default.
- W2000953040 cites W2014666371 @default.
- W2000953040 cites W2019610492 @default.
- W2000953040 cites W2021125340 @default.
- W2000953040 cites W2022673476 @default.
- W2000953040 cites W2027971163 @default.
- W2000953040 cites W2028221049 @default.
- W2000953040 cites W2035343693 @default.
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- W2000953040 cites W2041325323 @default.
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- W2000953040 cites W2056652163 @default.
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- W2000953040 cites W2058734213 @default.
- W2000953040 cites W2059429906 @default.
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- W2000953040 cites W2085152917 @default.
- W2000953040 cites W2088286107 @default.
- W2000953040 cites W2098272219 @default.
- W2000953040 cites W2099105062 @default.
- W2000953040 cites W2100349230 @default.
- W2000953040 cites W2104315543 @default.
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- W2000953040 cites W2143368326 @default.
- W2000953040 cites W2145914609 @default.
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- W2000953040 cites W2155186791 @default.
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- W2000953040 doi "https://doi.org/10.1016/j.ydbio.2008.08.012" @default.
- W2000953040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2653429" @default.
- W2000953040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18773886" @default.
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