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- W2000954311 abstract "The complement system plays a critical role in host innate immunity against microorganisms. Properdin, a basic glycoprotein of 442 amino acids, is a key component of the alternative complement pathway. 1 Nolan K.F. Reid K.B. Complete primary structure of human properdin: a positive regulator of the alternative pathway of the serum complement system. Biochem Soc Trans. 1990; 18: 1161-1162 PubMed Google Scholar , 2 Götze O. Müller-Eberhard H.J. The C3-activator system: an alternate pathway of complement activation. J Exp Med. 1971; 134: 90-108 Crossref PubMed Scopus (604) Google Scholar Properdin binds to C3 convertase, resulting in amplification and stabilization of the C3bBb complex and thus allowing for alternative pathway activation. [3] Fearon D.T. Austen K.F. Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase. J Exp Med. 1975; 142: 856-863 Crossref PubMed Scopus (302) Google Scholar" @default.
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- W2000954311 date "2014-06-01" @default.
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- W2000954311 title "Properdin deficiency–associated bronchiectasis" @default.
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- W2000954311 doi "https://doi.org/10.1016/j.anai.2014.04.003" @default.
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