FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000955709> ?p ?o ?g. }

• W2000955709 endingPage "10315" @default.
• W2000955709 startingPage "10301" @default.
• W2000955709 abstract "Despite the prevalence of insulin resistance and type 2 diabetes mellitus, their underlying mechanisms remain incompletely understood. Many secreted endocrine factors and the intertissue cross-talk they mediate are known to be dysregulated in type 2 diabetes mellitus. Here, we describe CTRP12, a novel adipokine with anti-diabetic actions. The mRNA and circulating levels of CTRP12 were decreased in a mouse model of obesity, but its expression in adipocytes was increased by the anti-diabetic drug rosiglitazone. A modest rise in circulating levels of CTRP12 by recombinant protein administration was sufficient to lower blood glucose in wild-type, leptin-deficient ob/ob, and diet-induced obese mice. A short term elevation of serum CTRP12 by adenovirus-mediated expression improved glucose tolerance and insulin sensitivity, normalized hyperglycemia and hyperinsulinemia, and lowered postprandial insulin resistance in obese and diabetic mice. CTRP12 improves insulin sensitivity in part by enhancing insulin signaling in the liver and adipose tissue. Further, CTRP12 also acts in an insulin-independent manner; in cultured hepatocytes and adipocytes, CTRP12 directly activated the PI3K-Akt signaling pathway to suppress gluconeogenesis and promote glucose uptake, respectively. Collectively, these data establish CTRP12 as a novel metabolic regulator linking adipose tissue to whole body glucose homeostasis through insulin-dependent and independent mechanisms." @default.
• W2000955709 created "2016-06-24" @default.
• W2000955709 creator A5007640637 @default.
• W2000955709 creator A5014099039 @default.
• W2000955709 creator A5043042092 @default.
• W2000955709 creator A5062512018 @default.
• W2000955709 creator A5067039252 @default.
• W2000955709 creator A5085389712 @default.
• W2000955709 creator A5091337382 @default.
• W2000955709 date "2012-03-01" @default.
• W2000955709 modified "2023-10-18" @default.
• W2000955709 title "C1q/TNF-related Protein-12 (CTRP12), a Novel Adipokine That Improves Insulin Sensitivity and Glycemic Control in Mouse Models of Obesity and Diabetes" @default.
• W2000955709 cites W1524321743 @default.
• W2000955709 cites W1587875569 @default.
• W2000955709 cites W1964985957 @default.
• W2000955709 cites W1974762968 @default.
• W2000955709 cites W1988109900 @default.
• W2000955709 cites W2000054651 @default.
• W2000955709 cites W2010188590 @default.
• W2000955709 cites W2010562302 @default.
• W2000955709 cites W2010774685 @default.
• W2000955709 cites W2010926945 @default.
• W2000955709 cites W2015970620 @default.
• W2000955709 cites W2020554122 @default.
• W2000955709 cites W2025327530 @default.
• W2000955709 cites W2032322539 @default.
• W2000955709 cites W2042706232 @default.
• W2000955709 cites W2044763541 @default.
• W2000955709 cites W2052777370 @default.
• W2000955709 cites W2054584654 @default.
• W2000955709 cites W2057091500 @default.
• W2000955709 cites W2062162775 @default.
• W2000955709 cites W2065705538 @default.
• W2000955709 cites W2069667907 @default.
• W2000955709 cites W2081359005 @default.
• W2000955709 cites W2083788791 @default.
• W2000955709 cites W2088986234 @default.
• W2000955709 cites W2101414552 @default.
• W2000955709 cites W2107940713 @default.
• W2000955709 cites W2108222684 @default.
• W2000955709 cites W2108765211 @default.
• W2000955709 cites W2110714384 @default.
• W2000955709 cites W2111645882 @default.
• W2000955709 cites W2122394887 @default.
• W2000955709 cites W2128319960 @default.
• W2000955709 cites W2143807925 @default.
• W2000955709 cites W2146168160 @default.
• W2000955709 cites W2153134360 @default.
• W2000955709 cites W2160234571 @default.
• W2000955709 cites W2161455288 @default.
• W2000955709 doi "https://doi.org/10.1074/jbc.m111.303651" @default.
• W2000955709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3322967" @default.
• W2000955709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22275362" @default.
• W2000955709 hasPublicationYear "2012" @default.
• W2000955709 type Work @default.
• W2000955709 sameAs 2000955709 @default.
• W2000955709 citedByCount "128" @default.
• W2000955709 countsByYear W20009557092012 @default.
• W2000955709 countsByYear W20009557092013 @default.
• W2000955709 countsByYear W20009557092014 @default.
• W2000955709 countsByYear W20009557092015 @default.
• W2000955709 countsByYear W20009557092016 @default.
• W2000955709 countsByYear W20009557092017 @default.
• W2000955709 countsByYear W20009557092018 @default.
• W2000955709 countsByYear W20009557092019 @default.
• W2000955709 countsByYear W20009557092020 @default.
• W2000955709 countsByYear W20009557092021 @default.
• W2000955709 countsByYear W20009557092022 @default.
• W2000955709 countsByYear W20009557092023 @default.
• W2000955709 crossrefType "journal-article" @default.
• W2000955709 hasAuthorship W2000955709A5007640637 @default.
• W2000955709 hasAuthorship W2000955709A5014099039 @default.
• W2000955709 hasAuthorship W2000955709A5043042092 @default.
• W2000955709 hasAuthorship W2000955709A5062512018 @default.
• W2000955709 hasAuthorship W2000955709A5067039252 @default.
• W2000955709 hasAuthorship W2000955709A5085389712 @default.
• W2000955709 hasAuthorship W2000955709A5091337382 @default.
• W2000955709 hasBestOaLocation W20009557091 @default.
• W2000955709 hasConcept C126322002 @default.
• W2000955709 hasConcept C134018914 @default.
• W2000955709 hasConcept C171089720 @default.
• W2000955709 hasConcept C194832188 @default.
• W2000955709 hasConcept C2777180221 @default.
• W2000955709 hasConcept C2777391703 @default.
• W2000955709 hasConcept C2779306644 @default.
• W2000955709 hasConcept C2780613262 @default.
• W2000955709 hasConcept C2780988686 @default.
• W2000955709 hasConcept C3018667095 @default.
• W2000955709 hasConcept C511355011 @default.
• W2000955709 hasConcept C555293320 @default.
• W2000955709 hasConcept C71924100 @default.
• W2000955709 hasConcept C86803240 @default.
• W2000955709 hasConceptScore W2000955709C126322002 @default.
• W2000955709 hasConceptScore W2000955709C134018914 @default.
• W2000955709 hasConceptScore W2000955709C171089720 @default.
• W2000955709 hasConceptScore W2000955709C194832188 @default.
• W2000955709 hasConceptScore W2000955709C2777180221 @default.
• W2000955709 hasConceptScore W2000955709C2777391703 @default.

• next