FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000956978> ?p ?o ?g. }

• W2000956978 endingPage "237" @default.
• W2000956978 startingPage "221" @default.
• W2000956978 abstract "The interleukin 1 (IL-1) receptor is a critical component in mediating the inflammatory responses of IL-1, which affect nearly every cell type. Recently, major inroads have been made toward understanding the mechanism by which IL-1 interacts with its receptor and activates signal transduction. The receptor-ligand association has been visualized by X-ray crystal structure analysis, revealing intimate details that distinguish IL-1beta from the naturally-occuring receptor antagonist. Signaling studies have focused primarily on the ability of IL-1 to transduce the activation of the transcription factor, NF-kappaB, which is of central importance to inflammatory and immune responses. Virtually all of the effort has targeted the activation of a kinase which results in the phosphorylation of the inhibitory IkappaB molecule at two serines that precedes the proteolytic degradation of this inhibitor and the release of active NF-kappaB. The recent characterization of an IL-1 receptor associated kinase (IRAK) and a continuous molecular path between this kinase and that which directly phosphorylates IkappaB would seem to all but close the basic understanding of IL-1 receptor signal transduction. However, at least half of the IL-1-dependent NF-kappaB activation is independent of IRAK and uses a novel pathway involving the recruitment of phosphatidylinositol 3-kinase (PI3K) to a distinct site within the cytoplasmic domain of the IL-1 receptor. This novel pathway for NF-kappaB activation and the fact that other important transcription factors are also activated by an IL-1 receptor-dependent signal event, clearly defines additional mechanisms that influence inflammation." @default.
• W2000956978 created "2016-06-24" @default.
• W2000956978 creator A5078347043 @default.
• W2000956978 date "1998-12-01" @default.
• W2000956978 modified "2023-10-17" @default.
• W2000956978 title "The Interleukin 1 Receptor: Ligand Interactions and Signal Transduction" @default.
• W2000956978 cites W1491925978 @default.
• W2000956978 cites W1515994079 @default.
• W2000956978 cites W1568165627 @default.
• W2000956978 cites W1568605582 @default.
• W2000956978 cites W1599671902 @default.
• W2000956978 cites W1770761484 @default.
• W2000956978 cites W1916260177 @default.
• W2000956978 cites W1947030034 @default.
• W2000956978 cites W1964842789 @default.
• W2000956978 cites W1965971815 @default.
• W2000956978 cites W1967413976 @default.
• W2000956978 cites W1973293243 @default.
• W2000956978 cites W1976424894 @default.
• W2000956978 cites W1976681032 @default.
• W2000956978 cites W1984339902 @default.
• W2000956978 cites W1984665850 @default.
• W2000956978 cites W1985118687 @default.
• W2000956978 cites W1986663284 @default.
• W2000956978 cites W1989166339 @default.
• W2000956978 cites W1989459539 @default.
• W2000956978 cites W1995507251 @default.
• W2000956978 cites W1998145026 @default.
• W2000956978 cites W1998160288 @default.
• W2000956978 cites W1998585620 @default.
• W2000956978 cites W2001399809 @default.
• W2000956978 cites W2003849027 @default.
• W2000956978 cites W2004986546 @default.
• W2000956978 cites W2008987764 @default.
• W2000956978 cites W2025864476 @default.
• W2000956978 cites W2030592815 @default.
• W2000956978 cites W2030624761 @default.
• W2000956978 cites W2032731042 @default.
• W2000956978 cites W2033549171 @default.
• W2000956978 cites W2034856894 @default.
• W2000956978 cites W2034974668 @default.
• W2000956978 cites W2036475326 @default.
• W2000956978 cites W2036602491 @default.
• W2000956978 cites W2040470926 @default.
• W2000956978 cites W2046950192 @default.
• W2000956978 cites W2050970992 @default.
• W2000956978 cites W2052054438 @default.
• W2000956978 cites W2052969831 @default.
• W2000956978 cites W2053128835 @default.
• W2000956978 cites W2055737651 @default.
• W2000956978 cites W2061665489 @default.
• W2000956978 cites W2064558057 @default.
• W2000956978 cites W2067680656 @default.
• W2000956978 cites W2074393911 @default.
• W2000956978 cites W2075012700 @default.
• W2000956978 cites W2076918198 @default.
• W2000956978 cites W2078136106 @default.
• W2000956978 cites W2078707053 @default.
• W2000956978 cites W2085837280 @default.
• W2000956978 cites W2087669979 @default.
• W2000956978 cites W2089938437 @default.
• W2000956978 cites W2090748712 @default.
• W2000956978 cites W2091695331 @default.
• W2000956978 cites W2095152292 @default.
• W2000956978 cites W2095416319 @default.
• W2000956978 cites W2099729324 @default.
• W2000956978 cites W2101168569 @default.
• W2000956978 cites W2102411042 @default.
• W2000956978 cites W2107230539 @default.
• W2000956978 cites W2107773056 @default.
• W2000956978 cites W2111449472 @default.
• W2000956978 cites W2113737846 @default.
• W2000956978 cites W2118897660 @default.
• W2000956978 cites W2120872281 @default.
• W2000956978 cites W2125499492 @default.
• W2000956978 cites W2131026799 @default.
• W2000956978 cites W2153829422 @default.
• W2000956978 cites W2156475226 @default.
• W2000956978 cites W2164682544 @default.
• W2000956978 cites W2173560213 @default.
• W2000956978 cites W4231459852 @default.
• W2000956978 doi "https://doi.org/10.1016/s1359-6101(98)00018-5" @default.
• W2000956978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9918122" @default.
• W2000956978 hasPublicationYear "1998" @default.
• W2000956978 type Work @default.
• W2000956978 sameAs 2000956978 @default.
• W2000956978 citedByCount "168" @default.
• W2000956978 countsByYear W20009569782012 @default.
• W2000956978 countsByYear W20009569782013 @default.
• W2000956978 countsByYear W20009569782015 @default.
• W2000956978 countsByYear W20009569782016 @default.
• W2000956978 countsByYear W20009569782017 @default.
• W2000956978 countsByYear W20009569782018 @default.
• W2000956978 countsByYear W20009569782019 @default.
• W2000956978 countsByYear W20009569782022 @default.
• W2000956978 countsByYear W20009569782023 @default.
• W2000956978 crossrefType "journal-article" @default.
• W2000956978 hasAuthorship W2000956978A5078347043 @default.

• next